A meta-analysis of dietary carbohydrate intake and inflammatory bowel disease risk: evidence from 15 epidemiology studies
A meta-analysis of dietary carbohydrate intake and inflammatory bowel disease risk: evidence from 15 epidemiology studies
复制标题
膳食碳水化合物摄入量与炎症性肠病风险的荟萃分析：来自 15 项流行病学研究的证据
DOI：
10.17235/reed.2018.5490/2018
复制
发表时间：
2019-01-01
影响因子：
2
通讯作者：
Xu, Li-Xiao
中科院分区：
文献类型：
--
作者：
Jin, Zhong-Qin;Lu, Hui-Gang;Xu, Li-Xiao
背景和目的：评估膳食总碳水化合物摄入量与炎症性肠病风险(IBD)之间关系的流行病学研究结果存在争议。方法：对PubMed、Embase、Web of Science和Medline数据库进行系统的文献检索，直至2017年9月。队列、病例对照或横断面设计研究报告了饮食中碳水化合物摄入量与IBD风险之间的关系。采用随机效应模型计算汇总优势比(OR)和相应的95%可信区间。结果：共纳入8篇文献，15篇研究，1,361例，符合纳入标准。膳食碳水化合物摄入量与IBD发病风险无显著相关性(OR=1.091，95%CI=0.817~1.455，I-2=31.6%，p(异质性)=0.116)，溃疡性结肠炎(UC)和克罗恩病(CD)的合并OR和95%CI分别为1.167(0.777~1.752)和1.010(0.630~1.618)。这些关联在欧洲和亚洲人群中也没有显著意义。结论：较高的膳食总碳水化合物摄入量与IBD风险没有显著关系。需要对大量人群进行进一步的研究来验证这种关系。
Background and purpose: epidemiological studies that assess the association of dietary total carbohydrate intake and inflammatory bowel disease risk (IBD) have yielded controversial results. Therefore, this study of various epidemiological studies was conducted in order to explore this relationship.Methods: a systematic literature search of the PubMed, Embase, Web of Science and Medline databases was performed up to September 2017. Cohort, case-control or cross-sectional design studies were included that reported the association of dietary carbohydrate intake and IBD risk. Summary odds ratio (OR) and the corresponding 95% CI were calculated using the random effects model.Results: a total of eight articles with 15 individual studies that included 1,361 cases were eligible according to the inclusion criteria. Dietary carbohydrate intake had a non-significant relationship with the risk of IBD (OR = 1.091, 95% CI = 0.817-1.455,I-2=31.6%,p(for heterogeneity) = 0.116).The pooled OR and 95% CI for ulcerative colitis (UC) and Crohn's disease (CD) with regard to dietary carbohydrate intake was 1.167 (0.777-1.752) and 1.010 (0.630-1.618), respectively. These associations were also non-significant in both European and Asia populations.Conclusions: a higher dietary total carbohydrate intake had a non-significant relationship with IBD risk. Further studies with large populations are needed to verify this relationship.