Geometrically complex 3D-printed phantoms for diffuse optical imaging.
Geometrically complex 3D-printed phantoms for diffuse optical imaging.
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DOI：
10.1364/boe.8.001754
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发表时间：
2017-03-01
影响因子：
3.4
通讯作者：
Hebden JC
中科院分区：
文献类型：
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作者：
Dempsey LA;Persad M;Powell S;Chitnis D;Hebden JC
模仿人类和动物组织光学特性的组织等效体模通常用于漫射光学成像研究，以表征仪器或评估图像重建方法。尽管已经生产了许多方法来生成在可见光和近红外波长下具有指定吸收和传输散射系数的固体模型，但构造方法通常非常耗时并且无法创建复杂的几何形状。我们提出了一种使用标准 3D 打印机生成模型的方法。我们设计了一个简单的配方，可以生产出具有精确已知光学特性的打印模型。为了说明该方法的功能，我们描述了基于 MRI 图集数据创建的解剖学精确、组织等效的早产儿头部光学模型，该模型具有中空的大脑空间。当将高对比度目标插入充满水性散射溶液的中空空间时，获得模型的漫射光学图像。
Tissue-equivalent phantoms that mimic the optical properties of human and animal tissues are commonly used in diffuse optical imaging research to characterize instrumentation or evaluate an image reconstruction method. Although many recipes have been produced for generating solid phantoms with specified absorption and transport scattering coefficients at visible and near-infrared wavelengths, the construction methods are generally time-consuming and are unable to create complex geometries. We present a method of generating phantoms using a standard 3D printer. A simple recipe was devised which enables printed phantoms to be produced with precisely known optical properties. To illustrate the capability of the method, we describe the creation of an anatomically accurate, tissue-equivalent premature infant head optical phantom with a hollow brain space based on MRI atlas data. A diffuse optical image of the phantom is acquired when a high contrast target is inserted into the hollow space filled with an aqueous scattering solution.