THE FMS-LIKE TYROSINE KINASE, A RECEPTOR FOR VASCULAR ENDOTHELIAL GROWTH-FACTOR
THE FMS-LIKE TYROSINE KINASE, A RECEPTOR FOR VASCULAR ENDOTHELIAL GROWTH-FACTOR
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DOI：
10.1126/science.1312256
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发表时间：
1992-02-21
期刊：
影响因子：
56.9
通讯作者：
WILLIAMS, LT
中科院分区：
文献类型：
--
作者：
DEVRIES, C;ESCOBEDO, JA;WILLIAMS, LT
FMS样酪氨酸激酶(Flt)是酪氨酸激酶家族中的一种跨膜受体。在COS细胞中表达Flt互补DNA可以特异性地高亲和力结合血管内皮生长因子，也被称为血管渗透因子(VEGF-VPF)，当注射到豚鼠皮肤中时，这种因子可以诱导血管通透性，并刺激内皮细胞增殖。在非洲爪哇卵母细胞中表达Flt可引起卵母细胞释放钙以响应血管内皮生长因子-VPF。这些发现表明，Flt编码一种血管内皮生长因子-VPF受体。
The fms-like tyrosine kinase (Flt) is a transmembrane receptor in the tyrosine kinase family. Expression of flt complementary DNA in COS cells conferred specific, high-affinity binding of vascular endothelial growth factor, also known as vascular permeability factor (VEGF-VPF), a factor that induces vascular permeability when injected in the guinea pig skin and stimulates endothelial cell proliferation. Expression of Flt in Xenopus laevis oocytes caused the oocytes to release calcium in response to VEGF-VPF. These findings show that flt encodes a receptor for VEGF-VPF.