Cell adhesion: old and new questions
Cell adhesion: old and new questions
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DOI：
10.1016/s0968-0004(99)01479-6
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发表时间：
1999-12-01
影响因子：
13.8
通讯作者：
Hynes, RO
中科院分区：
文献类型：
--
作者：
Hynes, RO
后生动物显然需要细胞粘附来保持自身在一起，但粘附作用远不止于此。粘附受体进行跨膜连接，将细胞外基质和邻近细胞连接到细胞内细胞骨架，并且它们也充当信号转导器。在这篇文章中，我简要地总结了我们目前的理解细胞粘附的分子基础和生物学后果，并讨论我们目前的知识如何揭示细胞粘附的特异性问题。我提供了一些关于细胞粘附分子和过程的进化的想法和推测，考虑它们与其他形式的细胞间通讯的相互关系，并讨论了当我们进入后基因组时代时，尚未解决的问题。
Metazoans clearly need cell adhesion to hold themselves together, but adhesion does much more than that. Adhesion receptors make transmembrane connections, Linking extracellular matrix and adjacent cells to the intracellular cytoskeleton, and they also serve as signal transducers. In this article, I briefly summarize our present understanding of the molecular basis and biological consequences of cell adhesion and discuss how our current knowledge sheds light on questions of specificity of cell adhesion. I offer some thoughts and speculations about the evolution of cell-adhesion molecules and processes, consider their inter-relationships with other forms of cell-cell communication and discuss unresolved questions ripe for investigation as we enter the postgenomic era.