Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies
Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies
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DOI：
10.2119/molmed.2009.00153
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发表时间：
2011-01-01
影响因子：
5.7
通讯作者：
Jeschke, Marc G.
中科院分区：
文献类型：
--
作者：
Gauglitz, Gerd G.;Korting, Hans C.;Jeschke, Marc G.
过多的疤痕是由于生理性伤口愈合的异常而形成的，并且可能在任何对深层真皮的侮辱之后出现。过多的疤痕会引起疼痛、瘙痒和挛缩，严重影响患者的生理和心理生活质量。关于增生性疤痕和瘢痕疙瘩形成的多项研究已经进行了几十年，并导致了大量的治疗策略来预防或减轻过度疤痕的形成。然而，大多数治疗方法在临床上仍然不令人满意，很可能是由于对瘢痕形成和伤口收缩过程的复杂机制了解不足。在这篇综述中，我们总结了目前对瘢痕疙瘩和增生性瘢痕形成的病理生理学的理解，并讨论了现有的治疗方法和新的治疗策略。(c) 2011年，范斯坦医学研究所，www.feinsteininstitute.org在线地址：hftp://www.molmed.org dol: 10.2119/molmed.2009.00153
Excessive scars form as a result of aberrations of physiologic wound healing and may arise following any insult to the deep dermis. By causing pain, pruritus and contractures, excessive scarring significantly affects the patient's quality of life, both physically and psychologically. Multiple studies on hypertrophic scar and keloid formation have been conducted for decades and have led to a plethora of therapeutic strategies to prevent or attenuate excessive scar formation. However, most therapeutic approaches remain clinically unsatisfactory, most likely owing to poor understanding of the complex mechanisms underlying the processes of scarring and wound contraction. In this review we summarize the current understanding of the pathophysiology underlying keloid and hypertrophic scar formation and discuss established treatments and novel therapeutic strategies. (c) 2011 The Feinstein Institute for Medical Research, www.feinsteininstitute.org Online address: hftp://www.molmed.org dol: 10.2119/molmed.2009.00153