Blood-brain barrier and chemotherapeutic treatment of brain tumors.
Blood-brain barrier and chemotherapeutic treatment of brain tumors.
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DOI：
10.1586/14737175.6.8.1199
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发表时间：
2006-08-01
影响因子：
4.3
通讯作者：
van Tellingen, Olaf
中科院分区：
文献类型：
--
作者：
de Vries, Nienke A;Beijnen, Jos H;van Tellingen, Olaf
血脑屏障（BBB）对维持CNS的稳态至关重要，因为它密切调节脑中间质液的组成。不幸的是，在CNS内生长的恶性肿瘤可能会使用相同的屏障逃避化疗药物，使这种疾病对大多数化疗方案难以治疗。这篇综述将概述血脑屏障在脑癌中的影响，并讨论为提高脑肿瘤的药物暴露所做的努力。虽然这篇综述将集中在BBB在原发性脑癌（恶性胶质瘤）中的作用，但也将简要讨论其对脑转移的影响。
The blood-brain barrier (BBB) is of pivotal importance to maintain homeostasis of the CNS, as it closely regulates the composition of the interstitial fluid in the brain. Unfortunately, malignancies that grow within the CNS may evade chemotherapeutic drugs using the same barrier, making this disease refractory to most chemotherapy regimens. This review will outline the impact of the BBB in brain cancer and discuss the efforts that have been made to enhance the drug exposure of brain tumors. Although this review will focus on the role of the BBB in primary brain cancer (malignant glioma), its impact on brain metastases will also be briefly discussed.