Qualitative changes in symptomatology as an effect of treatment with escitalopram in and major depressive disorder generalized anxiety disorder
Qualitative changes in symptomatology as an effect of treatment with escitalopram in and major depressive disorder generalized anxiety disorder
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DOI：
10.1007/s00406-007-0771-x
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发表时间：
2008-04-01
影响因子：
4.7
通讯作者：
Weiller, Emmanuelle
中科院分区：
文献类型：
--
作者：
Lecrubier, Yves;Dolberg, Ornah T.;Weiller, Emmanuelle
本文的目的是研究重度抑郁症（MDD）患者与广泛性焦虑症（GAD）患者与伴有焦虑症状的重度抑郁症患者之间的异同。使用汉密尔顿焦虑量表（HAMA）或Montgomery-angstrom - sberg抑郁评定量表（MADRS）测量症状的艾司西酞普兰随机双盲临床研究的数据进行分析。在治疗前后，以汇款为单位计算量表中每个项目对总分的贡献。大多数单项HAMA在广泛性焦虑症患者中的作用几乎相等。在MDD患者中，焦虑情绪、紧张、失眠和注意力集中这四种症状对HAMA总分的贡献最大。在广泛性焦虑症患者中，三种症状（紧张、睡眠和注意力集中）占MADRS总分的三分之二。相反，大多数MADRS项目对重度抑郁症患者的总分贡献相同。治疗至缓解后，MDD或GAD的残余症状与治疗前的症状相似。焦虑症状在重度抑郁症或广泛性焦虑症患者中非常常见，且症状模式相似。在这两种疾病中，残留症状的症状模式与治疗前的症状模式相似。
The purpose of this article is to examine the similarities and differences between patients with Major Depressive Disorder (MDD) versus Generalized Anxiety Disorder (GAD) versus MDD with anxiety symptoms. Data were analysed from all randomized double-blind clinical studies with escitalopram that measured symptoms using either Hamilton Anxiety Scale (HAMA) or Montgomery-angstrom sberg Depression Rating Scale (MADRS). The contribution of each item of a scale to the total score was calculated before and after treatment, in remitters. Most single items of the HAMA contribute nearly equally in patients with GAD. In patients with MDD, four symptoms (i.e. anxious mood, tension, insomnia and concentration) contribute to most to the HAMA total score. In patients with GAD, three symptoms (tension, sleep and concentration) contribute two-thirds of the MADRS total score. In contrast, most MADRS items contribute equally to the total score in patients with MDD. After treatment to remission, the profile of residual symptoms MDD or GAD was similar to the symptom profile before treatment. Anxiety symptoms are very common in patients with MDD or GAD, and the symptomatic pattern is similar. In both disorders, the symptomatic pattern of residual symptoms is similar to the pattern of symptoms before treatment.