Microarray analysis reveals previously unknown changes in Toxoplasma gondii-infected human cells
Microarray analysis reveals previously unknown changes in Toxoplasma gondii-infected human cells
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DOI：
10.1074/jbc.m100951200
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发表时间：
2001-06-29
影响因子：
4.8
通讯作者：
Boothroyd, JC
中科院分区：
文献类型：
--
作者：
Blader, IJ;Manger, ID;Boothroyd, JC
感染细胞内原生动物寄生虫弓形虫的细胞经历促炎细胞因子上调、细胞器重新分布和免于凋亡的保护。为了检查这些变化和其他变化的分子基础，使用由类似于 22,000 个已知基因组成的人类 cDNA 微阵列研究了感染弓形虫的人包皮成纤维细胞的基因表达谱。 和未表征的表达序列标签。感染早期（1-2小时），
Cells infected with the intracellular protozoan parasite Toxoplasma gondii undergo up-regulation of proinflammatory cytokines, organelle redistribution, and protection from apoptosis, To examine the molecular basis of these and other changes, gene expression pro files of human foreskin fibroblasts infected with Toxoplasma were studied using human cDNA microarrays consisting of similar to 22,000 known genes and uncharacterized expressed sequence tags. Early during infection (1-2 h),