An epitetrathiodioxopiperazine related to emestrin from Emericella foveolata
An epitetrathiodioxopiperazine related to emestrin from Emericella foveolata
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DOI：
10.1016/s0031-9422(97)00210-0
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发表时间：
1997-09-01
期刊：
影响因子：
3.8
通讯作者：
Kawai, KI
中科院分区：
文献类型：
--
作者：
Ooike, M;Nozawa, K;Kawai, KI
与大环抗真菌epidithiodioxopperazine， emstrin相关的epidithiodioxopperazine， secoemestrin C，最初从纹状Emericella striata和E. quadrilineata中分离，与epidithiodioxopperazine， emstrin B一起从E. foveolata早期状态的培养基中分离。培养2周后，菌丝体中产生泌乳素，培养液中产生去硫代泌乳素和紫罗兰酸。通过光谱学和化学研究确定了该化合物的结构。舍甲睾酮C可能是舍甲睾酮和/或舍甲睾酮B到去硫舍甲睾酮的关键中间体。1997爱思唯尔科学有限公司版权所有。
An epitetrathiodioxopiperazine, secoemestrin C, related to the macrocyclic antifungal epidithiodioxopiperazine, emestrin, originally isolated from Emericella striata and E. quadrilineata, was isolated along with the epitrithiodioxopiperazine, emestrin B, from the culture medium of the early state of E. foveolata. This fungus also produced emestrin in the mycelium and dethiosecoemestrin and violaceic acid in the culture broth after two weeks cultivation. The structure of secoemestrin C was established by spectroscopic and chemical investigation. Secoemestrin C may be the key intermediate from emestrin and/or emestrin B to dethiosecoemestrin. (C) 1997 Elsevier Science Ltd. All rights reserved.