Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the Human Cancer Protein Interaction Network.
Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the Human Cancer Protein Interaction Network.
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DOI：
10.1007/s10969-014-9185-y
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Szyperski T
中科院分区：
文献类型：
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作者：
Pulavarti SV;Huang YJ;Pederson K;Acton TB;Xiao R;Everett JK;Prestegard JH;Montelione GT;Szyperski T
解析了来自人Obscurin-like蛋白1的免疫球蛋白样结构域7和12的高质量溶液NMR结构。这两个结构域共享30%的序列同一性，并且如预期的，它们的结构相当相似。新结构有助于人类癌症相关蛋白的结构覆盖。结构域7中Arg 812的突变导致罕见的3-M综合征，并且该位点位于预测参与蛋白质-蛋白质相互作用的表面区域。
High-quality solution NMR structures of immunoglobulin-like domains 7 and 12 from human Obscurin-like protein 1 were solved. The two domains share 30 % sequence identity and their structures are, as expected, rather similar. The new structures contribute to structural coverage of human cancer associated proteins. Mutations of Arg 812 in domain 7 cause the rare 3-M syndrome, and this site is located in a surface area predicted to be involved in protein-protein interactions.