Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas
Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas
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DOI：
10.1007/s00432-008-0423-1
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发表时间：
2008-06
影响因子：
3.6
通讯作者：
D. Pehlivan;E. Gunduz;M. Gunduz;H. Nagatsuka;L. Beder;B. Cengiz;R. Rivera;K. Fukushima;S. Palanduz;S. Ozturk;N. Yamanaka;K. Shimizu
中科院分区：
文献类型：
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作者：
D. Pehlivan;E. Gunduz;M. Gunduz;H. Nagatsuka;L. Beder;B. Cengiz;R. Rivera;K. Fukushima;S. Palanduz;S. Ozturk;N. Yamanaka;K. Shimizu
目的和方法染色体杂合性缺失（LOH）表明存在失活的肿瘤抑制基因（TSG）。TSG的失活在头颈部鳞状细胞癌（HNSCC）的肿瘤发生中具有功能作用。基于最近推测的14号染色体TSG的证据，我们使用8个多态微卫星标记检测了50例HNSCCs的14q染色体LOH。结果检测到14q21.2 ~ 22.3（42.5%）、14q31（55%）和14q32.1(37%) 3个区域LOH率较高。通过统计学分析探讨LOH与临床病理表现的相关性。观察到最高LOH标志物与总生存率和无病生存率之间存在很强的相关性。结论14号染色体远端携带TSG可能导致HNSCCs的发生和/或进展。一些基因如CHES1、BMP4、SAV和PNN已在该地区作为候选肿瘤抑制基因出现。
Purpose and methodsLoss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs.ResultsThree regions were detected to have a high LOH rate which included 14q21.2-22.3 (42.5%), 14q31 (55%), and 14q32.1 (37%). The correlation between LOH and clinicopathological findings was investigated through statistical analyses. A strong correlation was observed between the highest LOH marker and the overall and disease-free survival.ConclusionsThe results suggest that the distal part of chromosome 14 may host a TSG that may lead to the development and/or progression of HNSCCs. Several genes such as CHES1, BMP4, SAV, and PNN have arisen as candidate tumor suppressors in the region.