Staging of head and neck tumors:: [18F]fluorodeoxyglucose positron emission tomography compared with physical examination and conventional imaging modalities
Staging of head and neck tumors:: [18F]fluorodeoxyglucose positron emission tomography compared with physical examination and conventional imaging modalities
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DOI：
10.1016/s0278-2391(03)00314-8
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发表时间：
2003-09-01
影响因子：
1.9
通讯作者：
Eyrich, GK
中科院分区：
文献类型：
--
作者：
Sigg, MB;Steinert, H;Eyrich, GK
目的：本研究的目的是评价[F-18]氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）在头颈部原发性和复发性肿瘤分期中的应用，并与常规临床方法进行比较（体格检查、超声检查、计算机断层扫描），并探讨FDG-PET扫描对治疗策略的影响。对FDG-PET和常规诊断方法的结果进行回顾性分析，并与活检结果或患者结局或两者进行比较。在6年的时间里，对56名患者进行了78项FDG-PET研究;其中24名在治疗前，54名怀疑有残留或复发的肿瘤。结果：FDG-PET诊断原发灶的敏感性为93%，特异性为100%，准确性为94%。在检测淋巴结部位时，分别观察到94%、97%和96%的相似结果。在检测肿瘤发生在躯干，结果分别为83%，100%和98%。McNemar检验未证明FDG-PET与评价的常规方法之间存在任何统计学显著差异。当与常规诊断测试结合使用时，22%的PET扫描提供了重要的额外信息。最后，11%的PET扫描导致治疗planning.Conclusions的变化：我们的研究结果表明，FDG-PET是一种可靠的方法来检测肿瘤的所有肿瘤部位。因此，我们建议常规进行FDG-PET扫描，作为经活检证实的头颈癌患者治疗前分期的第一步诊断。(C)2003年美国口腔颌面外科医师协会。
Purpose: The aims of this study were to evaluate the use of [F-18]fluorodeoxyglucose positron emission tomography (FDG-PET) in the staging of primary and recurrent tumors of the head and neck in comparison to routine clinical methods (physical examination, ultrasonography, computed tomography) and to investigate the effect of FDG-PET scanning on therapeutic strategy.Materials and Methods: Retrospective analysis of the results of FDG-PET and conventional diagnostic modalities were compared with biopsy results or patient outcome or both. In a period of 6 years, 78 FDG-PET studies were performed on 56 patients; 24 of them before therapy and 54 on suspicion of residual or recurrent tumor. The evaluation of the diagnostic results was performed separately for the primary site and the nodal sites of the neck and for tumor occurrence in the trunk.Results: In detecting the primary site, FDG-PET results reached a sensitivity of 93%, a specificity of 100%, and an accuracy of 94%. In detecting the nodal sites, similar results of 94%, 97%, and 96% were seen, respectively. In detecting tumor occurrence in the trunk, results were 83%, 100%, and 98%, respectively. The McNemar test did not prove any statistically significant difference between FDG-PET and the evaluated conventional methods. When used in conjunction with conventional diagnostic tests, 22% of the PET scans gave important additional information. Finally, 11% of the performed PET scans led to a change in therapeutic planning.Conclusions: Our results show that FDG-PET is a reliable method to detect tumors in all tumor sites. Therefore, we recommend that FDG-PET scanning be performed routinely as a first diagnostic step in pretherapeutic staging of patients with biopsy-proven head and neck cancer. (C) 2003 American Association of Oral and Maxillofacial Surgeons.