Mucocutaneous manifestations of HIV-infected patients in the era of HAART in Guangxi Zhuang Autonomous Region, China
Mucocutaneous manifestations of HIV-infected patients in the era of HAART in Guangxi Zhuang Autonomous Region, China
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DOI：
10.1111/j.1468-3083.2011.04429.x
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发表时间：
2013-03-01
影响因子：
9.2
通讯作者：
Lian, S.
中科院分区：
文献类型：
--
作者：
Han, J.;Lun, W. H.;Lian, S.
背景人类免疫缺陷病毒（HIV）感染和获得性免疫缺陷综合征（AIDS）常伴有多种皮肤粘膜表现。然而，在中国很少有关于HIV/AIDS相关皮肤粘膜表现的研究报道。目的探讨348例HIV感染者皮肤黏膜病变的发生情况及其与免疫抑制程度的关系。高效抗逆转录病毒治疗（HAART）对皮肤粘膜表现谱的影响也进行了评价。方法对2010年8月至2010年11月在广西龙潭医院就诊的348例HIV感染者进行横断面研究。收集的信息包括人口统计数据、艾滋病毒相关的皮肤粘膜疾病、CD 4细胞计数、艾滋病定义疾病和抗逆转录病毒疗法。结果62.9%的患者有皮肤黏膜病变。接受HAART治疗的患者皮肤粘膜病变的患病率低于未接受HAART治疗的患者（54.05%比88.76%，P
Background Human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) are frequently associated with diverse mucocutaneous manifestations. However, few studies of HIV/AIDS-related mucocutaneous manifestations have been reported in China. Objective To investigate the occurrence of mucocutaneous disorders and their relationship with the degree of immunosuppression in 348 HIV-infected Chinese patients. The influence of highly active antiretroviral therapy (HAART) on the spectrum of mucocutaneous manifestations was also evaluated. Methods A cross-sectional study was performed on 348 HIV-infected Chinese patients seen at the Guangxi Longtan Hospital from August 2010 to November 2010. Collected information included demographic data, HIV-associated mucocutaneous disorders, CD4 cell count, AIDS-defining illness and antiretroviral therapy. Results In this study, 62.9% of all patients had mucocutaneous disorders. The prevalence of mucocutaneous disorders in the patients who had received HAART was lower than in those without HAART (54.05% vs. 88.76%, P