Genetic polymorphisms of the IFNλ genes are associated with biochemical features in Han Chinese with HCV infection from Yunnan Province, China
Genetic polymorphisms of the IFNλ genes are associated with biochemical features in Han Chinese with HCV infection from Yunnan Province, China
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DOI：
10.1016/j.meegid.2013.11.013
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发表时间：
2014-01-01
影响因子：
3.2
通讯作者：
Xia, Xueshan
中科院分区：
文献类型：
--
作者：
Zhang, A-Mei;Ma, Ke;Xia, Xueshan
丙型肝炎病毒（HCV）是丙型肝炎疾病的致病因素，可导致慢性或严重的肝脏疾病。既往研究已发现IL28B基因多态性与HCV患者的治疗效果和病毒清除相关。我们的目的是测试三个 IFN lambda 基因（IL28A、IL28B 和 IL29）的遗传多态性是否与汉族人的 HCV 感染相关。我们收集了来自云南省的 261 名未经任何治疗的 HCV 感染者和 265 名匹配的正常对照者的全血。在这些受试者中，28.4% (74/261) 的 HCV 患者和 26.8% (71/265) 的对照者为男性。 10个SNP（rs8099917、rs10853728、rs11883177、rs12980602、rs4803224、rs11671087、rs11665818、rs8108008、rs7248931和rs30461），覆盖了整个区域对 IL28A、IL28B 和 IL29 基因进行基因分型。我们的结果表明，IFN lambda 基因多态性的基因型和等位基因与 HCV 感染之间没有关联。一种由 10 个 SNP 组成的单倍型 (TGCTGTGGAT) 在 HCV 患者中的出现频率 (11/522 = 2.1%) 显着高于对照组 (1/530 = 0.2%) (P = 0.003)。我们对每个 SNP 的生化特征和基因型进行了关联分析，发现具有某些 SNP 某些基因型的 HCV 患者与健康对照相比，其 ALT/AST 比值和总胆红素 (TBIL) 水平较高。我们的结果表明 IFN lambda 基因多态性可能与中国云南省 HCV 患者的临床特征相关。 (C) 2013 Elsevier B.V. 保留所有权利。
Hepatitis C virus (HCV) is the pathogenic factor for hepatitis C disease, which could lead to chronic or serious hepatic diseases. Previous studies have identified that the IL28B gene polymorphisms were associated with therapeutic effect and viral clearness of HCV patients. We aimed to test whether genetic polymorphisms of three IFN lambda genes (IL28A, IL28B and IL29) are associated with HCV infection in Han Chinese. We collected whole blood of 261 HCV infectious patients without any therapy and 265 matched normal controls from Yunnan Province. Among these subjects, 28.4% (74/261) of HCV patients and 26.8% (71/265) of controls were male. Ten SNPs (rs8099917, rs10853728, rs11883177, rs12980602, rs4803224, rs11671087, rs11665818, rs8108008, rs7248931, and rs30461), which covered the whole region of the IL28A, IL28B, and IL29 genes, were genotyped. Our results showed that there was no association between genotypes and alleles of the IFN lambda gene polymorphisms and HCV infection. One haplotype (TGCTGTGGAT), which was consisted of ten SNPs, showed a significantly higher frequency in HCV patients (11/522 = 2.1%) than in controls (1/530 = 0.2%) (P = 0.003). We performed association analyses for biochemical features and genotype of each SNP, and found that HCV patients with certain genotypes of some SNPs had a higher level of the ALT/AST ratio and total blood bilirubin (TBIL) compared to healthy controls. Our results suggested the IFN lambda gene polymorphisms might be associated with clinical features of HCV patients from Yunnan Province, China. (C) 2013 Elsevier B.V. All rights reserved.