Malignant Mesothelioma in the Thoracic Cavity of a Crj:CD(SD) Rat Characterized by Round Hyalinous Stroma
Malignant Mesothelioma in the Thoracic Cavity of a Crj:CD(SD) Rat Characterized by Round Hyalinous Stroma
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DOI：
10.1293/tox.23.103
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发表时间：
2010-06-01
影响因子：
1.2
通讯作者：
Tsuchitani, Minoru
中科院分区：
文献类型：
--
作者：
Doi, Takuya;Kotani, Yuri;Tsuchitani, Minoru
在104周龄雄性Crj：CD（SD）大鼠中发现自发性恶性间皮瘤。肿瘤散在分布于肺、心脏、纵隔胸膜和胸壁表面，并向肺泡隔转移。组织学上，小的扁平或立方形肿瘤细胞与间质一起增殖，形成几乎正常的乳头状结构，并对胶体铁染色和间皮素免疫组化染色呈阳性反应。圆形透明质基质明显，这是一个特征性特征，其可能原因如下：首先，在几个肿瘤细胞簇的中心形成少量胶原纤维，然后细胞簇像气球一样膨胀，胶原纤维增加。（J Toxicol Pathol 2010; 23：103-106）
Spontaneous malignant mesothelioma was found in a 104-week-old male Crj:CD(SD) rat. The tumor was scattered on the surface of the lung, heart, mediastinal pleura and thoracic wall and metastasized to the alveolar septa. Histopathologically, small flattened or cuboidal tumor cells proliferated with stroma, formed almost normal papillary structures and reacted positively to colloidal iron stain and immunohistochemical staining for mesothelin. Round hyalinous stromata were pronounced, which is a characteristic feature, and the possible reason for this is as follows; at first, a small amount of collagen fibers was formed in the center of the clusters of several tumor cells, and then the cell clusters expanded like balloons with an increase in the collagen fibers. (J Toxicol Pathol 2010; 23: 103-106)