Is ethnicity a risk factor for severe retinopathy of prematurity?
Is ethnicity a risk factor for severe retinopathy of prematurity?
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DOI：
10.1136/adc.2009.160366
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发表时间：
2010-05-01
影响因子：
4.4
通讯作者：
Butler, Lucilla
中科院分区：
文献类型：
--
作者：
Aralikatti, Anil K. V.;Mitra, Arijit;Butler, Lucilla
目的评估不同种族早产儿视网膜病变（ROP）的危险性，设计ROP筛查和治疗的回顾性观察研究。它涉及对所有符合条件的婴儿进行为期七年的横断面审查。使用的统计检验是Kruskal-Wallis检验和Mann-Whitney U检验。Logistic回归用于控制出生体重和胎龄的任何差异，设置城市医院和伯明翰妇女医院，伯明翰，英国。与白色婴儿（1196.5 g）相比，黑人婴儿（1142.5 g）和亚洲婴儿（1180 g）的出生体重较低。黑人婴儿的胎龄（28.5周）低于亚洲和白色婴儿（均为29周）。与白色婴儿相比，亚洲婴儿（比值比（OR）：2.52; 95% CI 1.41 - 4.50）和黑人婴儿（OR：2.51; 95% CI 1.30 - 4.86）中需要治疗的重度ROP的比值更高。即使在校正出生体重和胎龄后，种族的额外风险仍然存在（亚裔与白色婴儿的校正OR：2.45; 95%CI 1.334至4.497）;（黑人与白色婴儿的校正OR：2.0; 95%CI 1.004至4.014）。与白色婴儿相比，亚裔和黑人婴儿发生阈值ROP的风险更高。
Objective To assess the risk of severe retinopathy of prematurity (ROP) requiring treatment in different ethnic groups.Design Retrospective observational study on ROP screening and treatment. It involved a cross-sectional review of all eligible infants over a seven-year period. Statistical tests used were the Kruskal-Wallis test and Mann-Whitney U test. Logistic regression was used to control for any differences in birth weight and gestational age.Setting City Hospital and Birmingham Women's Hospital, Birmingham, UK.Results 1690 preterm infants underwent ROP screening. Birth weight was lower in black (1142.5 g) and Asian infants (1180 g) when compared to white infants (1196.5 g). Gestational age was lower in black infants (28.5 weeks) compared to Asian and white infants (both 29 weeks). Compared to white infants, the odds of severe ROP requiring treatment was higher in Asian infants (odds ratio (OR): 2.52; 95% CI 1.41 to 4.50) and black infants (OR: 2.51; 95% CI 1.30 to 4.86). The additional risk from ethnicity was present even after adjusting for birth weight and gestational age (adjusted OR for Asian vs white infants: 2.45; 95% CI 1.334 to 4.497); (adjusted OR for black vs white infants: 2.0; 95% CI 1.004 to 4.014).Conclusions Ethnicity is a risk factor for severe ROP. Asian and black infants have a higher risk of developing threshold ROP compared to white infants.