Potency of Barleria prionitis L. bark extracts against oral diseases causing strains of bacteria and fungi of clinical origin
Potency of Barleria prionitis L. bark extracts against oral diseases causing strains of bacteria and fungi of clinical origin
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Barleria prionitis L.树皮提取物对引起临床来源的细菌和真菌菌株的口腔疾病的功效
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发表时间：
2010
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通讯作者：
C. Sharma
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作者：
K. R. Aneja;Radhika N. Joshi;C. Sharma
口腔健康是整体健康不可或缺的一部分，与生活质量相关，而生活质量超出了颅面复合体的功能。传统上，植物为新型药物化合物提供了希望之源，因为植物草药混合物为人类健康和福祉做出了巨大贡献。我们在这项工作中首次报道了 Barleria prionotis L. 树皮对与人类口腔疾病有关的两种白色念珠菌菌株和酿酒酵母的有效抗真菌活性。筛选了丙酮、甲醇、乙醇、巴氏杆菌树皮的水（热和冷）提取物对四种口腔细菌变形链球菌、金黄色葡萄球菌、假单胞菌属、芽孢杆菌属的体外活性。以及三种口腔真菌白色念珠菌菌株1、白色念珠菌菌株2和酿酒酵母。选择这种植物是因为它传统上用于治疗口腔感染。三种临床菌株，即假单胞菌属、芽孢杆菌属。和白色念珠菌菌株 2 是从受龋齿影响的患者中分离出来的。朊病毒芽孢杆菌提取物在琼脂平板上的抗菌活性在不同溶剂中有所不同。 B.prionitis 的甲醇树皮提取物对所有四种口腔细菌和三种口腔真菌最有效。芽孢杆菌属。被发现是最敏感的病原体，其存活率高达 12.5mg/ml，因此 MIC 为 25mg/ml。 B.prionitis 树皮对芽孢杆菌的抗菌潜力。与标准抗生素药物、阳性对照环丙沙星相当，后者产生 29.65mm 的抑菌圈。有趣的是，B.prionitis 树皮的甲醇提取物对所有测试的口腔真菌（即酿酒酵母、白色念珠菌菌株 1 和白色念珠菌菌株 2）表现出比标准药物两性霉素 -B 更有效的活性，因此在控制念珠菌病和其他口腔真菌感染方面具有巨大潜力。 （纽约科学杂志 2010 年；3(11):5-12）。 （ISSN：1554-0200）。
Oral health is integral to general well being and relates to the quality of life that extends beyond the functions of craniofacial complex. Plants have traditionally provided a source of hope for novel drug compounds, as plant herbal mixtures have made large contributions to human health and well-being. We report in this work for the first time, the potent antifungal activity of Barleria prionotis L. bark on two Candida albicans strains and Saccharomyces cerevisiae, involved in oral diseases of human. Acetone, methanol, ethanol, aqueous (hot and cold) extracts of Barleria prionitis bark were screened for in vitro activity against four oral bacteria Streptococcus mutans, Staphylococcus aureus, Pseudomonas sp., Bacillus sp. and three oral fungi C.albicans strain 1, C.albicans strain 2 and S.cerevisiae. This plant was selected due to its traditional use for the treatment of oral infections. Three clinical strains namely Pseudomonas sp., Bacillus sp. and Candida albicans strain 2 were isolated from dental caries affected patients. The antimicrobial activity of B.prionitis extracts on the agar plates varied in different solvents. The methanolic bark extract of B. prionitis was the most effective against all the four oral bacteria and the three oral fungi. Bacillus sp. was found to be the most sensitive pathogen which survived upto 12.5mg/ml, thus having an MIC of 25mg/ml. The antimicrobial potential of B.prionitis bark against Bacillus sp. was comparable with the standard antibiotic drug, the positive control, ciprofloxacin which produced a 29.65mm inhibition zone. Interestingly the methanolic extract of B.prionitis bark showed much more potent activity against all the tested oral fungi namely S.cerevisiae, C.albicans strain 1 and C.albicans strain 2, than the standard drug amphotericin -B thus having a great potential to control candidiasis and other oral fungal infections. (New York Science Journal 2010;3(11):5-12). (ISSN: 1554-0200).