International Symposium on the biomedical effects of ozone and related photochemical oxidants
International Symposium on the biomedical effects of ozone and related photochemical oxidants
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臭氧及相关光化学氧化剂的生物医学效应国际研讨会
DOI：
10.1080/00039896.1970.10665624
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
M. Mehlman
中科院分区：
文献类型：
--
作者：
S. D. Lee;M. Mustafa;M. Mehlman
幼鼠（4 天以及 1 个月和 2 个月大）每天暴露于 0.6 至 1.3 ppm（1.4 至 2.8 毫克每立方米）的臭氧中六至七小时，持续一到两天。肺泡细胞的形态变化与年龄和剂量有关。最敏感的是暴露两天的最小小鼠（4天大）。小毛细血管内壁的内皮细胞似乎是臭氧的主要目标。在许多部分，内衬膜已破裂并破碎。基底膜通常是完整的。一些红细胞被破坏。很少有血气屏障被完全打破的情况。细胞碎片通常存在于肺泡和毛细血管中。大肺泡角或壁细胞的细胞质的一些混乱是明显的。在暴露一天的老年动物中观察到不太广泛的形态变化。
Young mice (4 days and 1 and 2 months old) were exposed to 0.6 to 1.3 ppm (1.4 to 2.8 mg per cu m) ozone for six to seven hours per day for one or two days. The morphological changes seen in the alveolar cells were both age- and dose-dependent; most sensitive were the youngest mice (4 days old) exposed for two days. The endothelial cells lining the small capillaries appeared to be the main target of the ozone. In many sections the lining membranes were broken and fragmenting. The basement membrane was usually intact. Some erythrocytes were disrupted. Infrequently the blood-air barrier was completely broken. Cell debris was often present in the alveoli as well as the capillaries. Some disorganization of the cytoplasm of the large alveolar corner or wall cells was evident. Less extensive morphological change was seen in the older animals exposed for one day.