ADENOVIRUS VAI RNA ANTAGONIZES THE ANTIVIRAL ACTION OF INTERFERON BY PREVENTING ACTIVATION OF THE INTERFERON-INDUCED ELF-2-ALPHA KINASE
ADENOVIRUS VAI RNA ANTAGONIZES THE ANTIVIRAL ACTION OF INTERFERON BY PREVENTING ACTIVATION OF THE INTERFERON-INDUCED ELF-2-ALPHA KINASE
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DOI：
10.1016/0092-8674(86)90383-1
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发表时间：
1986-04-25
期刊：
影响因子：
64.5
通讯作者：
SHENK, T
中科院分区：
文献类型：
--
作者：
KITAJEWSKI, J;SCHNEIDER, RJ;SHENK, T
腺病毒的VAI RNA是一种小的RNA聚合酶III转录的物质，在注射后后期有效翻译宿主细胞和病毒mRNA所需。不能产生RNA的病毒突变体的生长被干扰素抑制，而野生型病毒不受影响。VAI RNA阻止干扰素诱导的P1/eIF-2 α的激活。激酶。这种抑制作用可以在干扰素处理的细胞提取物中重现，其中纯化的VAI RNA防止双链RNA激活潜伏激酶。
The VAI RNA of adenovirus is a small, RNA polymerase III-transcribed species required for efficient translation of host cell and viral mRNAs late after injection. The growth of a viral mutant that is unable to produce the RNA is inhibited by interferon, while wild-type virus is not affected. VAI RNA prevents activation of the interferon-induced P1/eIF-2.alpha. kinase. This inhibition can be reproduced in extracts of interferon-treated cells where purified VAI RNA prevents activation of latent kinase by double-stranded RNA.