From amnesia to dementia: ERP studies of memory and language.
From amnesia to dementia: ERP studies of memory and language.
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DOI：
10.1177/155005940703800106
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发表时间：
2007-01-01
影响因子：
2
通讯作者：
Olichney, John M.
中科院分区：
文献类型：
--
作者：
Taylor, Jason R.;Olichney, John M.
本文综述了认知事件相关电位（ERP）对遗忘症和阿尔茨海默病（AD）记忆和语言障碍的研究。内侧颞叶（MTL）或间脑的明确病变导致遗忘综合征，即无法编码和提取超出短暂工作记忆持续时间的情景记忆，似乎会改变晚期阳性P600成分的可塑性，但通常会保留P300和N400成分。AD的神经病理学影响MTL并延伸到新皮质关联区，导致情节和语义记忆的缺陷。在AD痴呆中，P300、N400和P600均出现异常，对轻度认知障碍者进行ERP研究，可以揭示AD患者出现临床缺陷前的神经生理学改变，从而促进AD的早期发现和诊断。
Cognitive event-related potential (ERP) studies of memory and language impairments in amnesia and Alzheimer's disease (AD) are reviewed. Well-circurnscribed lesions of the medial temporal lobe (MTL) or diencephalon causing an amnestic syndrome, an inability to encode and retrieve episodic memories beyond the brief duration of working memory, appear to produce altered plasticity of the late positive P600 component, but usually spare P300 and N400 components. The neuropathology of AD affects MTL and extends to neocortical association areas, causing deficits of episodic and semantic memory. In AD dementia, the P300, N400, and P600 all commonly show abnormalities, ERP studies of individuals with mild cognitive impairment may reveal neurophysiological changes prior to the emergence of clinical deficits, which could advance the early detection and diagnosis of AD.