Combined effects of smoking and HPV16 in oropharyngeal cancer
Combined effects of smoking and HPV16 in oropharyngeal cancer
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DOI：
10.1093/ije/dyw069
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发表时间：
2016-06-01
影响因子：
7.7
通讯作者：
Brennan, Paul
中科院分区：
文献类型：
--
作者：
Anantharaman, Devasena;Muller, David C.;Brennan, Paul
背景资料：虽然吸烟和HPV感染被认为是口咽癌的重要危险因素，但它们的联合暴露如何影响口咽癌风险尚不清楚。具体而言，吸烟是否赋予任何额外的风险HPV阳性口咽cancerisnotundered.Methods：使用HPV血清学作为HPV相关癌症的标志物，我们研究了吸烟和HPV 16之间的相互作用459口咽（和1445口腔和喉）癌患者和3024对照组参与者从两个大型欧洲多中心研究。结果：吸烟（OR [CrI]：6.82 [4.52，10.29]）和HPV血清阳性（OR [CrI]：235.69 [99.95，555.74]）与口咽癌独立相关。吸烟和HPV血清阳性的联合协会是一致的，预期的添加剂规模（协同指数[CrI]：1.32 [0.51，3.45]），这表明他们作为独立的危险因素口咽cancer.Conclusions：吸烟一直与口咽癌的风险增加模型分层的HPV 16血清阳性。此外，我们报告说，口咽癌的患病率增加吸烟的HPV 16阳性和HPV 16阴性的人。吸烟对HPV 16阳性口咽癌的影响突出表明，继续需要戒烟计划作为头颈癌的一级预防。
Background: Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPV-positive oropharyngeal cancer is not understood.Methods: Using HPV serology as a marker of HPV-related cancer, we examined the interaction between smoking and HPV16 in 459 oropharyngeal (and 1445 oral cavity and laryngeal) cancer patients and 3024 control participants from two large European multicentre studies. Odds ratios and credible intervals [CrI], adjusted for potential confounders, were estimated using Bayesian logistic regression.Results: Both smoking [odds ratio (OR [CrI]: 6.82 [4.52, 10.29]) and HPV seropositivity (OR [CrI]: 235.69 [99.95, 555.74]) were independently associated with oropharyngeal cancer. The joint association of smoking and HPV seropositivity was consistent with that expected on the additive scale (synergy index [CrI]: 1.32 [0.51, 3.45]), suggesting they act as independent risk factors for oropharyngeal cancer.Conclusions: Smoking was consistently associated with increase in oropharyngeal cancer risk in models stratified by HPV16 seropositivity. In addition, we report that the prevalence of oropharyngeal cancer increases with smoking for both HPV16-positive and HPV16-negative persons. The impact of smoking on HPV16-positive oropharyngeal cancer highlights the continued need for smoking cessation programmes for primary prevention of head and neck cancer.