Identification of distant family relationships
Identification of distant family relationships
复制标题
DOI：
10.1093/bioinformatics/btp418
复制
发表时间：
2009-09-15
期刊：
影响因子：
5.8
通讯作者：
Egeland, Thore
中科院分区：
文献类型：
--
作者：
Skare, Oivind;Sheehan, Nuala;Egeland, Thore
动机：家庭关系可以通过DNA标记数据来估计。应用出现在大量的领域，包括进化和保护研究，人类，植物和动物种群的系谱研究，法医问题和遗传图谱通过连锁和关联分析。传统上，基于似然性的关系估计方法使用非连锁的遗传标记。由于某些关系不能与未连锁标记处的数据区分开的事实，并且鉴于可用的这种标记的数量有限，因此对于可以用这种方法令人满意地解决的识别问题的类型存在相当大的限制。本文的目的是探讨潜在的连锁常染色体单核苷酸多态性标记在这种情况下。在整个过程中，我们将把关系估计的问题，作为一个血统鉴定，而不是身份的下降，从而专注于应用程序中确定的确切关系是important.Results：我们表明，通过利用大型连锁标记集获得的信息的增加，大大增加了可以解决的问题的数量。结果是基于模拟以及真实的数据。
Motivation: Family relationships can be estimated from DNA marker data. Applications arise in a large number of areas including evolution and conservation research, genealogical research in human, plant and animal populations, forensic problems and genetic mapping via linkage and association analyses. Traditionally, likelihood-based approaches to relationship estimation have used unlinked genetic markers. Due to the fact that some relationships cannot be distinguished from data at unlinked markers, and given the limited number of such markers available, there are considerable constraints on the type of identification problem that can be satisfactorily addressed with such approaches. The aim of this article is to explore the potential of linked autosomal single nucleotide polymorphism markers in this context. Throughout, we will view the problem of relationship estimation as one of pedigree identification rather than identity-by-descent, and thus focus on applications where determination of the exact relationship is important.Results: We show that the increase in information obtained by exploiting large sets of linked markers substantially increases the number of problems that can be solved. Results are presented based on simulations as well as on real data.