Segregated expression of neurestin in the developing olfactory bulb.
Segregated expression of neurestin in the developing olfactory bulb.
复制标题
神经素在发育中的嗅球中分离表达。
DOI：
10.1097/00001756-199908200-00044
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发表时间：
1999
期刊：
影响因子：
1.7
通讯作者：
Firestein,S
中科院分区：
文献类型：
--
作者：
Otaki,JM;Firestein,S
NeURESTIN是一种可能的跨膜蛋白，其在神经元中的表达受发育调控。在这里，我们研究了发育中的大鼠嗅球二尖瓣/簇状细胞中Neurestin的表达模式。在主要嗅球中，Neurestin的表达在背喙区和腹尾区分离，但在两者之间不分离。在副嗅球，Neurestin的表达仅见于远尾侧。这一区域并不完全对应于犁鼻神经和肾小球层的尾侧半部分，G蛋白GOα阳性。这些时空表达模式表明，neurestin作为一种靶标识别分子，指定了嗅觉和犁鼻感觉神经元的带状投射模式。
NEURESTIN is a putative transmembrane protein whose expression is developmentally regulated in neurons. Here we examined neurestin expression pattern in mitral/tufted cells in the developing rat olfactory bulb. In the main olfactory bulb, neurestin expression was segregated in the dorso-rostral area and in the ventrocaudal area, but not in between. In the accessory olfactory bulb, neurestin expression was found only in the far caudal area. This area did not completely correspond to a caudal half of the vomeronasal nerve and glomerular layers positive for a G-protein Goα. These spatio-temporal expression patterns suggest that neurestin functions as a target recognition molecule that specifies zonal projection patterns of olfactory and vomeronasal sensory neurons.