Amygdala volume in late-life depression: relationship with age of onset.
Amygdala volume in late-life depression: relationship with age of onset.
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DOI：
10.1097/jgp.0b013e318211069a
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发表时间：
2011-09
期刊：
影响因子：
--
通讯作者：
Taylor WD
中科院分区：
文献类型：
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作者：
Burke J;McQuoid DR;Payne ME;Steffens DC;Krishnan RR;Taylor WD
抑郁症在老年人中很常见。虽然许多神经影像学研究已经检查了抑郁的老年人，但研究杏仁核体积如何与抑郁症相关的研究有限。比较有和无重度抑郁症诊断的老年人以及早期和晚期抑郁发作的抑郁受试者杏仁核体积的横断面检查学术医疗中心91例符合《精神疾病诊断和统计手册》第四版重度抑郁症标准的老年患者（54例早发性抑郁症和37例晚发性抑郁症）和31例无任何精神病诊断的老年受试者。杏仁核和脑容量的测量使用可靠的手动跟踪方法。在控制了年龄、性别和大脑体积的模型中，双侧杏仁核体积的诊断队列之间存在显著差异（左侧：F[2，116]= 16.28，p <0.0001;右侧：F[2，116]= 16.28，p <0.0001）。使用最小二乘均值组分析，早发性和迟发性抑郁症受试者的双侧杏仁核体积均小于非抑郁症队列（所有比较p <0.0001），但两个抑郁症队列没有表现出统计学显著差异。局限性包括缺失抗抑郁治疗数据，回忆偏倚，无法建立杏仁核大小和抑郁症之间的因果关系，考虑到设计的横截面性质。老年抑郁症与杏仁核体积较小有关，与抑郁症初始发作的年龄无关。
Depression is common in the elderly population. Although numerous neuroimaging studies have examined depressed elders, there is limited research examining how amygdala volume may be related to depression. A cross-sectional examination of amygdala volume comparing elders with and without a diagnosis of major depressive disorder, and between depressed subjects with early and later initial depression onset. An academic medical center. Ninety-one elderly patients meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for major depression (54 early-onset depressed and 37 late-onset depressed) and 31 elderly subjects without any psychiatric diagnoses. Amygdala and cerebral volumes were measured using reliable manual tracing methods. In models controlling for age, sex, and cerebral volume, there was a significant difference between diagnostic cohorts in amygdala volume bilaterally (left: F[2, 116]= 16.28, p <0.0001; right: F[2, 116]= 16.28, p <0.0001). Using least squares mean group analyses, both early- and late-onset depressed subjects exhibited smaller bilateral amygdala volumes than did the nondepressed cohort (all comparisons p <0.0001), but the two depressed cohorts did not exhibit a statistically significant difference. Limitations include missing antidepressant treatment data, recall bias, inability to establish a causal relationship between amygdala size and depression given the cross-sectional nature of the design. Depression in later life is associated with smaller amygdala volumes, regardless of age of initial onset of depression.