A Compact Clinical Instrument for Quantifying Suppression
A Compact Clinical Instrument for Quantifying Suppression
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DOI：
10.1097/opx.0b013e318205a162
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发表时间：
2011-02-01
影响因子：
1.4
通讯作者：
Hess, Robert F.
中科院分区：
文献类型：
--
作者：
Black, Joanne M.;Thompson, Benjamin;Hess, Robert F.
目的.我们描述了一个紧凑和方便的临床仪器的抑制测量的基础上，以前报道的实验室为基础的方法。此外，我们报告和验证了一种新的，快速的心理物理方法测量抑制使用该设备，这使得该技术更适用于临床实践。通过使用由MAC笔记本电脑驱动的Z 800双pro头戴式显示器，我们提供了双视刺激。向每只眼睛呈现由移动点阵列组成的全局运动刺激。一组点沿相干方向移动（称为信号），而另一组点沿随机方向移动（称为噪声）。为了量化性能，我们测量对应于方向辨别阈值的信号/噪声比。通过评估哪只眼睛看到信号和哪只眼睛看到噪声的重要程度来量化抑制。使用当前视频技术的节省空间的头戴式显示器为临床实践提供了理想的解决方案。此外，我们优化的心理物理方法提供的结果与使用原始技术产生的结果一致。我们对一组9名成年弱视参与者使用该仪器与原始和新的心理物理范式进行了抑制措施。所有参与者都有可测量的抑制，从轻度到重度。两种不同的心理物理学方法给出了抑制强度的强相关性（rho =-0.83，p = 0.006）。新仪器与新的心理物理学方法相结合，为眼间抑制的参数测量提供了一种方便快捷的方法。此外，该装置构成了抑制者的理想平台，以类似于双目正常人的方式在他们的眼睛之间联合收割机组合信息。这为临床医生实施新提出的基于抗抑制训练的弱视双眼治疗提供了一种方便的方法。（Optom维斯科学2011; 88：E334-E343）
Purpose. We describe a compact and convenient clinical apparatus for the measurement of suppression based on a previously reported laboratory-based approach. In addition, we report and validate a novel, rapid psychophysical method for measuring suppression using this apparatus, which makes the technique more applicable to clinical practice.Methods. By using a Z800 dual pro head-mounted display driven by a MAC laptop, we provide dichoptic stimulation. Global motion stimuli composed of arrays of moving dots are presented to each eye. One set of dots move in a coherent direction (termed signal) whereas another set of dots move in a random direction (termed noise). To quantify performance, we measure the signal/noise ratio corresponding to a direction-discrimination threshold. Suppression is quantified by assessing the extent to which it matters which eye sees the signal and which eye sees the noise.Results. A space-saving, head-mounted display using current video technology offers an ideal solution for clinical practice. In addition, our optimized psychophysical method provided results that were in agreement with those produced using the original technique. We made measures of suppression on a group of nine adult amblyopic participants using this apparatus with both the original and new psychophysical paradigms. All participants had measurable suppression ranging from mild to severe. The two different psychophysical methods gave a strong correlation for the strength of suppression (rho = -0.83, p = 0.006).Conclusion. Combining the new apparatus and new psychophysical method creates a convenient and rapid technique for parametric measurement of interocular suppression. In addition, this apparatus constitutes the ideal platform for suppressors to combine information between their eyes in a similar way to binocularly normal people. This provides a convenient way for clinicians to implement the newly proposed binocular treatment of amblyopia that is based on antisuppression training. (Optom Vis Sci 2011; 88:E334-E343)