Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese - The Japan Public Health Center-based (JPHC) Study Cohort I
Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese - The Japan Public Health Center-based (JPHC) Study Cohort I
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DOI：
10.1161/circulationaha.105.581355
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发表时间：
2006-01-17
期刊：
影响因子：
37.8
通讯作者：
Tsugane, S
中科院分区：
文献类型：
--
作者：
Iso, H;Kobayashi, M;Tsugane, S
在西方国家，每周食用一次或两次鱼（或少量鱼的摄入量）可以降低冠心病和心源性猝死的风险。目前还不确定是否高频率或大量的鱼类摄入量，如在日本的情况下，进一步降低风险。方法和结果-检查高摄入量的鱼类和n3多不饱和脂肪酸和冠心病的风险之间的关联，共有41578名年龄在40至59岁之间的日本男性和女性，他们先前没有心血管疾病和癌症的诊断，并完成了食物频率问卷，从1990 - 1992年到2001年进行了随访。经过477325人年的随访，记录了258例冠心病事件（198例明确心肌梗死和23例可能心肌梗死和37例心脏性猝死），包括196例非致命性和62例致命性冠状动脉事件。多变量风险比（HR）和95%置信区间最高（每周8次，或中位摄入量= 180 g/d）与最低（每周一次，或中位摄入量= 23 g/d）鱼类摄入量的五分位数为0.63冠心病组为0.38 ~ 1.04，心肌梗死组为0.44（0.24 ~ 0.81），心源性猝死组为1.14（0.36 ~ 3.63）。主要观察到非致死性冠状动脉事件的风险降低（HR = 0.43 [0.23 - 0.81]），但致死性冠状动脉事件的风险未降低（HR = 1.08 [0.42 - 2.76]）。膳食中n3脂肪酸的摄入与明确的心肌梗死风险之间存在强的负相关性（HR = 0.35 [0.18 - 0.66]）和非致死性冠状动脉事件（HR = 0.33 [0.17至0.63]）。结论-与每周一次或约20 g/d的适度鱼类摄入量相比，在中年人中，高摄入量与冠心病（主要是非致命性心脏事件）的风险大幅降低有关。
Background - Once- or twice-weekly consumption of fish ( or a small amount of fish intake) reduces the risk of coronary heart disease and sudden cardiac death in Western countries. It is uncertain whether a high frequency or large amount of fish intake, as is the case in Japan, further reduces the risk.Methods and Results - To examine an association between high intake of fish and n3 polyunsaturated fatty acids and the risk of coronary heart disease, a total of 41 578 Japanese men and women aged 40 to 59 years who were free of prior diagnosis of cardiovascular disease and cancer and who completed a food frequency questionnaire were followed up from 1990 - 1992 to 2001. After 477 325 person-years of follow-up, 258 incident cases of coronary heart disease ( 198 definite and 23 probable myocardial infarctions and 37 sudden cardiac deaths) were documented, comprising 196 nonfatal and 62 fatal coronary events. The multivariable hazard ratios (HRs) and 95% confidence intervals in the highest ( 8 times per week, or median intake = 180 g/d) versus lowest ( once a week, or median intake = 23 g/d) quintiles of fish intake were 0.63 (0.38 to 1.04) for total coronary heart disease, 0.44 (0.24 to 0.81) for definite myocardial infarction, and 1.14 (0.36 to 3.63) for sudden cardiac death. The reduced risk was primarily observed for nonfatal coronary events (HR = 0.43 [0.23 to 0.81]) but not for fatal coronary events ( HR = 1.08 [0.42 to 2.76]). Strong inverse associations existed between dietary intake of n3 fatty acids and risk of definite myocardial infarction ( HR = 0.35 [0.18 to 0.66]) and nonfatal coronary events ( HR = 0.33 [0.17 to 0.63]).Conclusions - Compared with a modest fish intake of once a week or approximate to 20 g/d, a higher intake was associated with substantially reduced risk of coronary heart disease, primarily nonfatal cardiac events, among middle- aged persons.