Network Dynamics in the Developing Piriform Cortex of Unanesthetized Rats.
Network Dynamics in the Developing Piriform Cortex of Unanesthetized Rats.
复制标题
未麻醉大鼠梨状皮层发育中的网络动力学。
DOI：
10.1093/cercor/bhaa300
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Maier,JoostX
中科院分区：
文献类型：
--
作者：
Zhang,Zihao;Collins,DonaldChad;Maier,JoostX
在啮齿动物视觉系统中，已经广泛研究了早期发育过程中功能性皮层活动变化的时间过程。这个过程中的一个关键时期是眼睛睁开的时间，这标志着模式化视觉输入和主动视觉的开始。然而，视觉与其他系统的不同之处在于，它在睁开眼睛之前接受有限的模式化感觉输入，并且仍然不清楚视觉的发现与其他系统的关系。在这里，我们专注于发展的皮质网络活动的嗅觉系统，这是至关重要的生存在出生时，通过记录场电位和尖峰活动从梨状皮质的未麻醉大鼠幼崽出生（P0）到P21。我们的研究结果表明，气味引起稳定的10-15赫兹振荡梨状皮质从出生到P15，之后皮质反应经历了快速的变化。这种转变与伽马振荡和快速嗅探行为的出现是一致的，并且在自发活动增加之前。新生儿的网络振荡和他们的发展动力学表现出惊人的相似性与以前观察到的视觉，听觉和体感系统，提供洞察网络水平的机制，一般的感觉皮层的发展，特别是嗅觉处理。
The time course of changes in functional cortical activity during early development has been extensively studied in the rodent visual system. A key period in this process is the time of eye opening, which marks the onset of patterned visual input and active vision. However, vision differs from other systems in that it receives limited patterned sensory input before eye opening, and it remains unclear how findings from vision relate to other systems. Here, we focus on the development of cortical network activity in the olfactory system—which is crucial for survival at birth—by recording field potential and spiking activity from piriform cortex of unanesthetized rat pups from birth (P0) to P21. Our results demonstrate that odors evoke stable 10–15 Hz oscillations in piriform cortex from birth to P15, after which cortical responses undergo rapid changes. This transition is coincident with the emergence of gamma oscillations and fast sniffing behavior and preceded by an increase in spontaneous activity. Neonatal network oscillations and their developmental dynamics exhibit striking similarities with those previously observed in the visual, auditory, and somatosensory systems, providing insight into the network-level mechanisms underlying the development of sensory cortex in general and olfactory processing in particular.