Predictive values of anti-cyclic citrullinated peptide antibodies and rheumatoid factor in relation to serological aspects of the ACR/EULAR 2010 classification criteria for rheumatoid arthritis
Predictive values of anti-cyclic citrullinated peptide antibodies and rheumatoid factor in relation to serological aspects of the ACR/EULAR 2010 classification criteria for rheumatoid arthritis
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DOI：
10.1080/03009742.2019.1609079
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发表时间：
2019-06-30
影响因子：
2.1
通讯作者：
Lillevang, S. T.
中科院分区：
文献类型：
--
作者：
Tenstad, H. B.;Nilsson, A. C.;Lillevang, S. T.
目的：在这项基于人群的回顾性登记研究中，我们希望确定免疫球蛋白M类风湿因子（IgM RF）和抗葫芦氨酸化蛋白抗体（ACPAs）在正常上限（UNL）的3倍时的阳性预测值（PPVs），因为它们在美国风湿病学会(ACR)/欧洲抗风湿病联盟（EULAR） 2010年类风湿关节炎（RA）标准中权重相等。方法：收集2007年至2016年欧登塞大学医院临床免疫科的检测结果、订购单位、检测日期和患者社会安全号码，并与丹麦国家患者登记处的患者诊断合并。结果：IgM RF在3倍UNL时的PPV为14%，而ACPAs在3倍UNL时的PPV为43%。结论：3倍UNL时，ACPAs的PPV高于IgM RF的PPV。这些发现没有反映在ACR/EULAR 2010类风湿性关节炎的分类标准中。
Objective: In this retrospective population-based register study, we wanted to determine the positive predictive values (PPVs) of immunoglobulin M rheumatoid factor (IgM RF) and anti-citrullinated protein antibodies (ACPAs) at 3 x upper normal limit (UNL), since they are weighted equally in the American College of Rheumatology (ACR)/ European League Against Rheumatism (EULAR) 2010 criteria for rheumatoid arthritis (RA). Methods: Test results, ordering unit, test date, and patient social security number were collected from the Department of Clinical Immunology at Odense University Hospital from 2007 to 2016 and merged with patient diagnosis from the Danish National Patient Registry. Results: The PPV of IgM RF at 3 x UNL was 14%, compared to a PPV of 43% for ACPAs at 3 x UNL. Conclusion: The PPV of ACPAs is higher than the PPV of IgM RF at 3 x UNL. These findings are not reflected in the ACR/EULAR 2010 classification criteria for RA.