Difference in the characteristics of subjective and objective sleepiness between narcolepsy and essential hypersomnia
Difference in the characteristics of subjective and objective sleepiness between narcolepsy and essential hypersomnia
复制标题
DOI：
10.1111/j.1440-1819.2005.01357.x
复制
发表时间：
2005-04-01
影响因子：
11.9
通讯作者：
Honda, Y
中科院分区：
文献类型：
--
作者：
Komada, Y;Inoue, Y;Honda, Y
本研究旨在探讨发作性睡病与原发性嗜睡症患者日间嗜睡特征的差异，并探讨两种疾病患者Epworth嗜睡量表（ESS）与多重睡眠潜伏期测试（MSLT）的关系。研究对象包括34例原发性嗜睡症患者（32.4 +/- 11.0岁），52例发作性睡症患者（29.0 +/- 13.8岁）和45例对照组（33.3 +/- 6.6岁）。受试者完成ESS并按照常规睡眠-觉醒时间表进行MSLT，时间超过2周。不仅在发作性睡病中，而且在原发性嗜睡症中，MSLT的ESS评分高且平均睡眠潜伏期短。对于每次MSLT的睡眠潜伏期，原发性嗜睡和对照组在14:00时的值最小，而发作性睡在这个时间段没有任何统计学变化。重度嗜睡患者的ESS与平均睡眠潜伏期之间的相关性高于发作性睡症患者，并且在14:00进行的会话中相关性最强。根据ESS和MSLT结果，原发性嗜睡症患者白天过度嗜睡的严重程度明显轻于发作性睡症患者。结果还表明，与发作性睡病相比，原发性嗜睡症的嗜睡程度维持了昼夜变化，主客观嗜睡程度的相关性相对维持。提示原发性嗜睡症的轻度疾病严重程度促成了这些特征的形成。
The present study was conducted to investigate the difference in the characteristics of daytime sleepiness between narcolepsy and essential hypersomnia and to identify the relationship between the Epworth Sleepiness Scale (ESS) and the Multiple Sleep Latency Test (MSLT) in patients with these two disorders. Subjects consisted of 34 patients with essential hypersomnia (32.4 +/- 11.0 years old), 52 patients with narcolepsy (29.0 +/- 13.8 years old), and 45 control subjects (33.3 +/- 6.6 years old). The subjects completed the ESS and underwent MSLT following a regular sleep-wake schedule for over 2 weeks. The ESS scores were pathologically high and mean sleep latency on MSLT was short, not only in narcolepsy but also in essential hypersomnia. With respect to sleep latencies on each MSLT session, both essential hypersomnia and control subjects had the smallest value at 14:00, while narcolepsy lacked any statistical change at this time period. The correlation between ESS and mean sleep latency on MSLT was higher in essential hypersomnia than in narcolepsy, and the correlation was strongest for the session performed at 14:00. Based on the ESS and MSLT results, the severity of excessive daytime sleepiness was significantly milder in essential hypersomnia compared with that in narcolepsy. The results also indicate that diurnal variation of sleepiness was maintained, and the correlation between subjective and objective sleepiness was relatively maintained in essential hypersomnia compared to narcolepsy. It is suggested that the mild disease severity of essential hypersomnia contributed to the formation of these characteristics.