A soil-inspired dynamically responsive chemical system for microbial modulation
A soil-inspired dynamically responsive chemical system for microbial modulation
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DOI：
10.1038/s41557-022-01064-2
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发表时间：
2022-10-24
期刊：
影响因子：
21.8
通讯作者：
Tian, Bozhi
中科院分区：
文献类型：
--
作者：
Lin, Yiliang;Gao, Xiang;Tian, Bozhi
微生物群与其定殖环境之间的相互作用介导了从生物地球化学循环到人类健康稳态的关键途径。在这里，我们报告了一个由纳米结构矿物质、淀粉颗粒和液态金属组成的土壤启发化学系统。通过自下而上的合成，土壤激发的化学系统可以使微生物群落的化学再分配和调节。我们对复合材料进行了表征，用三维x射线荧光、体表断层扫描和电子显微镜成像证实了其与土壤的结构相似性。我们还证明了激光照射形成的合成后修饰导致从原子到宏观水平的化学非均质性。这种受土壤启发的材料具有化学、光学和机械反应能力，在电性能上具有写入擦除功能。复合材料还可以促进微生物培养/生物膜的生长和生物燃料的体外生产。最后，我们发现土壤激发系统丰富了肠道细菌多样性，纠正了四环素诱导的肠道微生物群失调，并改善了葡聚糖硫酸钠诱导的啮齿动物结肠炎症状。
Interactions between the microbiota and their colonized environments mediate critical pathways from biogeochemical cycles to homeostasis in human health. Here we report a soil-inspired chemical system that consists of nanostructured minerals, starch granules and liquid metals. Fabricated via a bottom-up synthesis, the soil-inspired chemical system can enable chemical redistribution and modulation of microbial communities. We characterize the composite, confirming its structural similarity to the soil, with three-dimensional X-ray fluorescence and ptychographic tomography and electron microscopy imaging. We also demonstrate that post-synthetic modifications formed by laser irradiation led to chemical heterogeneities from the atomic to the macroscopic level. The soil-inspired material possesses chemical, optical and mechanical responsiveness to yield write-erase functions in electrical performance. The composite can also enhance microbial culture/biofilm growth and biofuel production in vitro. Finally, we show that the soil-inspired system enriches gut bacteria diversity, rectifies tetracycline-induced gut microbiome dysbiosis and ameliorates dextran sulfate sodium-induced rodent colitis symptoms within in vivo rodent models.