In vitro models of inhalation toxicity and disease. The report of a FRAME workshop.
In vitro models of inhalation toxicity and disease. The report of a FRAME workshop.
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DOI：
10.1177/026119290903702s03
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发表时间：
2009-12
期刊：
影响因子：
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通讯作者：
K. BéruBé;M. Aufderheide;D. Breheny;R. Clothier;R. Combes;R. Duffin;B. Forbes;M. Gaca;A. Gray;Ian Hall;Michael Kelly;M. Lethem;M. Liebsch;Leona Merolla;J. Morin;J. Seagrave;M. Swartz;T. Tetley;M. Umachandran
中科院分区：
文献类型：
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作者：
K. BéruBé;M. Aufderheide;D. Breheny;R. Clothier;R. Combes;R. Duffin;B. Forbes;M. Gaca;A. Gray;Ian Hall;Michael Kelly;M. Lethem;M. Liebsch;Leona Merolla;J. Morin;J. Seagrave;M. Swartz;T. Tetley;M. Umachandran
总结了诺丁汉大学医学院FRAME替代实验室的研究目的，即使用基于人类细胞培养的项目和人类志愿者体内研究作为人类疾病研究中使用啮齿动物模型的替代方法。当现有的动物模型不能充分代表人类的病理生理学情况时，这一点尤其重要。这种方法的例子是总结研究饥饿对骨骼肌的影响，在人类志愿者和肥胖女性志愿者的脂质代谢。
The aim of research in the FRAME Alternatives Laboratory at the University of Nottingham Medical School is summarised, i.e. to use human cell culture-based projects and in vivo studies in human volunteers as alternatives to the use of rodent models in the study of human disease. This is especially important when the available animal models do not adequately represent the pathophysiological situation in humans. The approach is exemplified by summaries of studies on the effects of starvation on skeletal muscle in human volunteers, and on lipid metabolism in obese female volunteers.