Intraindividual variation of glycohemoglobin: implications for interpretation and analytical goals.
Intraindividual variation of glycohemoglobin: implications for interpretation and analytical goals.
复制标题
糖血红蛋白的个体内变异：对解释和分析目标的影响。
作者：
G. Phillipou;P. Phillips
糖化血红蛋白(GHb)的个体内变异(CVI)是通过对稳定或可变临床对照的糖尿病患者的系列测量来估计的。用亲和柱法测定GHb，分析不精密度为4.9%(加权平均；GHb8.2-14.7%)。在患者组中，同时使用短期(28-32天)和长期(约85天)抽样方案。每种类型的CVI分别为4.2%(n=16，稳定，短期)、7.1%(n=23，稳定，长期)、5.1%(n=13，可变，短期)和9.8%(n=21，可变，长期)。每个类别内的平均GHB相似(约11%)，不同类别之间的GHB值在统计学上没有显著差异。结果表明，GHB的CVI受临床控制和采样时间间隔的影响。这些研究结果对于估计温室气体连续测量之间的重大差异和制定适当的分析精确度目标具有重要意义。
Intraindividual variation (CVi) for glycohemoglobin (GHb) was estimated from serial measurements in patients with diabetes in either stable or variable clinical control. GHb determinations were performed by an affinity column procedure with an analytical imprecision of 4.9% (weighted average; GHb 8.2-14.7%). Within the groups of patients, both a short- (28-32 days) and long-term (approximately 85 days) sampling protocol was used. The derived CVi for each category was 4.2% (n = 16, stable, short-term), 7.1% (n = 23, stable, long-term), 5.1% (n = 13, variable, short-term), and 9.8% (n = 21, variable, long-term). The mean GHb within each category was similar (approximately 11%), and there was no statistically significant difference in GHb values between categories. The results establish that the CVi for GHb is affected by both clinical control and the sampling time interval. These findings have important implications for the estimation of significant differences between serial GHb measurements and the setting of appropriate analytical precision goals.