Expression of a myeloid marker on TdT-positive acute lymphocytic leukemic cells: evidence by double-fluorescence staining.
Expression of a myeloid marker on TdT-positive acute lymphocytic leukemic cells: evidence by double-fluorescence staining.
复制标题
TdT 阳性急性淋巴细胞白血病细胞上骨髓标记物的表达：双荧光染色证据。
作者：
P. Bettelheim;E. Paietta;O. Majdic;H. Gadner;J. Schwarzmeier;W. Knapp
在两例儿童急性淋巴细胞白血病中检测到TdT阳性原始细胞群的髓系特异性抗原表达。双荧光染色，通过使用单克隆抗体，VIM-D5，这是特异性的骨髓来源的细胞，与TdT抗血清相结合，揭示了一个独特的部分的母细胞携带这两种标志物。这一发现代表了白血病细胞中这种特异性双表型的首次直接证明，并被解释为淋巴母细胞上髓样抗原的异常表达。
The expression of a myeloid-specific antigen was detected on TdT-positive blast cell populations in two cases of childhood acute lymphocytic leukemia. Double-fluorescence staining by using the monoclonal antibody, VIM-D5, which is specific for cells of myeloid origin, in combination with TdT antiserum revealed that a distinct portion of the blast cells carried both markers. The finding represents the first direct demonstration of this specific biphenotype in leukemic cells and was interpreted as the abnormal expression of a myeloid antigen on lymphoid blast cells.
DOI：
10.1073/pnas.77.11.6764
发表时间：
1980
影响因子：
11.1
作者：
Ugolini,V;Nunez,G;Smith,RG;Stastny,P;Capra,JD
通讯作者：
Capra,JD