Visual evoked potentials during long periods of pattern-reversal stimulation in migraine
Visual evoked potentials during long periods of pattern-reversal stimulation in migraine
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DOI：
10.1093/brain/121.2.233
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发表时间：
1998-02-01
期刊：
影响因子：
14.5
通讯作者：
Schoenen, J
中科院分区：
文献类型：
--
作者：
Afra, J;Cecchini, AP;Schoenen, J
我们先前已经证明，在持续2分钟的重复模式反转刺激期间，偏头痛患者发作间歇期的视觉诱发电位(PR-VEP)的幅度增加，而健康对照组的PR-VEP幅度降低。根据Sappy-Marinier等人的说法。正常受试者PR-VEP的习惯化在12个月后达到最大，此时仪式枕叶皮质刺激增强的乳酸水平降低。因此，我们比较了健康对照组(n=25)和无症状偏头痛患者(n=25)和有先兆偏头痛患者(n=15)在长时间重复刺激期间的PR-VEP。在3.1赫兹的不间断刺激中，对100个反应块的VEP进行顺序平均，总持续时间为15min，并根据N1-P1和P1-N2峰的潜伏期和峰间幅度进行分析。计算每一块与第一块相比的波幅变化，并用Zerbe方法进行统计分析。偏头痛患者第一块的NI-PI和P1-N_2波幅往往低于健康对照组。在15分钟的刺激过程中，对照组的两种成分的波幅逐渐降低，但在两组患者中保持稳定。患者组与对照组之间差异有统计学意义(P<；0.05)。神经生理学数据仅与发作频率或病程等临床特征无关。这些结果是偏头痛发作间歇期皮质信息处理习惯化缺陷的又一证明，这可能有利于在持续激活期间感觉皮质的乳酸积累。
We have previously shown that during repetitive pattern reversal stimulation, lasting 2 min, the amplitude of the visual evoked potential (PR-VEP) increases in migraineurs wizen tested interictally whereas it decreases in healthy control subjects. According to Sappey-Marinier et al. (J Cereb Blood Flow Metab 1992; 12: 584-92) habituation of the PR-VEP in normal subjects is maximal after 12 mil?, at a time when there is a decrease of stimulation-enhanced lactate levels in rite occipital cortex. We have therefore compared PR-VEP during long periods of repetitive stimulation in healthy control subjects (n = 25) and in patients suffering from migraine without (n = 25) and with aura (n = 15) between attacks. During uninterrupted stimulation at 3.1 HZ VEPs were sequentially averaged in blocks of 100 responses for a total duration of 15 min and analysed in terms of latencies and peak-to-peak amplitudes of N1-P1 and P1-N2 peaks. Amplitude changes from the baseline were calculated for each block, by comparison with the first block, and analysed statistically using Zerbe's method The NI-PI and P1-N2 amplitudes in the first block tended to be lower in migraineurs than in healthy control subjects. During the 15 min of stimulation, amplitudes of both components progressively decreased in control subjects, but remained stable in both groups of patients. The difference between patients and control subjects proved to be significant (P < 0.05). The neurophysiological data Mere not correlated with clinical features such as attack frequency or duration of illness. These results are yet another demonstration in migraine of an interictal habituation deficit in cortical information processing, which might favour lactate accumulation in sensory cortices during sustained activation.