Switchable Cobalt-Catalyzed α-Olefination and α-Alkylation of Nitriles with Primary Alcohols
Switchable Cobalt-Catalyzed α-Olefination and α-Alkylation of Nitriles with Primary Alcohols
复制标题
钴催化的伯醇对腈的α-烯烃化和α-烷基化
DOI：
10.1021/acs.orglett.1c01553
复制
发表时间：
2021
期刊：
影响因子：
5.2
通讯作者：
Ding, Keying
中科院分区：
文献类型：
--
作者：
Paudel, Keshav;Xu, Shi;Ding, Keying
首次报道了过渡金属钴碱配合物催化腈与伯醇的α-烯烃化和α-烷基化反应。通过这种方法，多种腈和伯醇被选择性地和有效地转化为相应的产物。值得注意的是，该转化是环境友好的和原子效率的，H2和H2O是唯一的副产物。
The first switchable α-olefination and α-alkylation of nitriles with primary alcohols catalyzed by a well-defined base transition-metal Co complex was presented. A broad variety of nitriles and primary alcohols are selectively and efficiently converted to the corresponding products by this method. It is noteworthy that the transformation is environmentally benign and atom efficient with H2and H2O being the sole byproducts.