Amygdala central nucleus function is necessary for learning but not expression of conditioned visual orienting
Amygdala central nucleus function is necessary for learning but not expression of conditioned visual orienting
复制标题
DOI：
10.1111/j.0953-816x.2004.03458.x
复制
发表时间：
2004-07-01
影响因子：
3.4
通讯作者：
Holland, PC
中科院分区：
文献类型：
--
作者：
McDannald, M;Kerfoot, E;Holland, PC
当暴露于视觉刺激与食物传递的配对时，大鼠通常获得针对视觉刺激的条件定向反应和与食物相关的条件反应。与先前的病变研究结果一致，每次条件反射前杏仁核中央核功能的可逆性失活阻止了条件定向反应的获得，而与食物相关的行为是正常获得的。相比之下，中央核的失活和神经毒性病变都不影响先前获得的条件定向反应的表达。因此，中央核显然不是维持条件定向所需的信息的关键，而是其他地方的记忆存储所必需的。本文讨论了条件定向回路的组成部分的特殊作用，包括中央核、黑质和背外侧纹状体。
When exposed to pairings of a visual stimulus with food delivery, rats normally acquire both conditioned orienting responses directed toward the visual stimulus and conditioned food-related responses. Consistent with the results of previous lesion studies, reversible inactivation of amygdala central nucleus function before each conditioning session prevented the acquisition of conditioned orienting responses, whereas food-related behaviors were acquired normally. By contrast, neither inactivation nor neurotoxic lesions of central nucleus affected the expression of previously acquired conditioned orienting responses. Thus, the central nucleus is apparently not critical to the maintenance of information required for conditioned orienting, but instead is necessary for memory storage elsewhere. Specialized roles for components of a circuit for conditioned orienting, which includes the central nucleus, the substantia nigra, and dorsolateral striatum, are discussed.