UBIQUITIN DEPOSITS IN ANTERIOR HORN CELLS IN MOTOR NEURON DISEASE
UBIQUITIN DEPOSITS IN ANTERIOR HORN CELLS IN MOTOR NEURON DISEASE
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DOI：
10.1016/0304-3940(88)90081-x
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发表时间：
1988-11-11
影响因子：
2.5
通讯作者：
POWER, DM
中科院分区：
文献类型：
--
作者：
LEIGH, PN;ANDERTON, BH;POWER, DM
一种多克隆抗血清泛素，低分子量蛋白参与ATP依赖性的异常细胞质蛋白的去除，已被用来染色脊髓从10例运动神经元疾病和12个控制脊髓。所有10例运动神经元疾病表现出抗泛素免疫反应性存款的比例存活的前角细胞，但这些存款没有看到在任何的12个控制。这些泛素沉积不对应于先前描述的运动神经元疾病的神经元包涵体。因此，泛素沉积物代表了一种新的神经元内含物，可能反映了以前未识别的脆弱神经元中发生的降解事件。
A polyclonal antiserum to ubiquitin, a low molecular weight protein involved in the ATP-dependent removal of abnormal cytoplasmic proteins, has been used to stain spinal cord from 10 cases of motor neurone disease and from 12 control spinal cords. All 10 cases of motor neurone disease exhibited antiubiquitin-immunoreactive deposits in a proportion of the surviving anterior horn cells but these deposits were not seen in any of the 12 controls. These ubiquitin deposits do not correspond to previously described neuronal inclusions in motor neurone disease. The ubiquitin deposits represent, therefore, a new neuronal inclusion which possibly reflects previously unrecognised degradative events occurring in the vulnerable neurones.