Diet-induced central obesity and insulin resistance in rabbits
Diet-induced central obesity and insulin resistance in rabbits
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DOI：
10.1111/j.1439-0396.2007.00723.x
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发表时间：
2008-02-01
影响因子：
2.7
通讯作者：
Liu, E.
中科院分区：
文献类型：
--
作者：
Zhao, S.;Chu, Y.;Liu, E.
本研究旨在探讨高脂高糖饲料喂养家兔是否会导致肥胖和胰岛素抵抗（IR），这是代谢综合征的主要病理生理特征。雄性日本白色家兔饲喂正常饲料（对照）或高脂肪和蔗糖饲料（HFSD）36周。测定血浆甘油三酯（TG）、总胆固醇（TC）、血糖和胰岛素水平。为了评估葡萄糖代谢，我们进行了静脉葡萄糖耐量试验。此外，我们比较了HFSD喂养的家兔与正常家兔的脂肪组织积累。HFSD持续且显著地导致HFSD喂养的兔的体重增加，这是由显著更高的内脏脂肪组织积累引起的。虽然两组之间的血浆TG、TC、葡萄糖、胰岛素水平和血压没有差异，但HFSD喂养的兔显示出与对照兔相比更高水平的胰岛素分泌相关的葡萄糖清除受损。结果表明，HFSD可诱导家兔胰岛素抵抗，增加脂肪蓄积，提示HFSD可作为研究人类胰岛素抵抗和肥胖的动物模型。
The present study was designed to examine whether rabbits fed a diet containing high fat and sucrose could develop obesity and insulin resistance (IR), the major pathophysiological features of metabolic syndrome. Male Japanese white rabbits were fed either a normal chow diet (control) or high fat and sucrose diet (HFSD) for 36 weeks. Plasma levels of triglycerides (TG), total cholesterol (TC), glucose and insulin were measured. To evaluate glucose metabolism, we performed an intravenous glucose tolerance test. In addition, we compared adipose tissue accumulation in HFSD-fed rabbits with that in normal rabbits. HFSD constantly and significantly led to an increase in body weight of HFSD-fed rabbits, caused by significantly higher visceral adipose tissue accumulation. Although there were no differences in plasma TG, TC, glucose, insulin levels and blood pressure between the two groups, HFSD-fed rabbits showed impaired glucose clearance associated with higher levels of insulin secretion compared to control rabbits. Our results showed that HFSD induced IR and increased adipose accumulation in rabbits, suggesting that HFSD-fed rabbits may become a model for research on human IR and obesity.