Comparison of pathogenicities of H7 avian influenza viruses via intranasal and conjunctival inoculation in cynomolgus macaques
Comparison of pathogenicities of H7 avian influenza viruses via intranasal and conjunctival inoculation in cynomolgus macaques
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DOI：
10.1016/j.virol.2016.03.007
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发表时间：
2016-06-01
期刊：
影响因子：
3.7
通讯作者：
Ogasawara, Kazumasa
中科院分区：
文献类型：
--
作者：
Shichinohe, Shintaro;Itoh, Yasushi;Ogasawara, Kazumasa
中国H7N9低致病性禽流感病毒的爆发引起了人们对人类感染H7流感病毒的关注。由于我们已经证明H1N1和H5N1流感病毒在猕猴中的致病性与在人类中的致病性几乎相同，我们通过鼻内接种和结膜接种比较了H7禽流感病毒在食蟹猕猴中的致病性，这两种方法模拟了人类的自然感染。H7N9病毒和H7N7高致病性禽流感病毒在猕猴中的复制效率和致病性均高于H7N1和H7N3高致病性禽流感病毒。这些结果与以前报道的鸡致病性不同。因此，我们在猕猴中获得的结果有助于估计H7禽流感病毒对人类的致病性。(C) 2016 Elsevier Inc.版权所有。
The outbreak of H7N9 low pathogenic avian influenza viruses in China has attracted attention to H7 influenza virus infection in humans. Since we have shown that the pathogenicity of H1N1 and H5N1 influenza viruses in macaques was almost the same as that in humans, we compared the pathogenicities of H7 avian influenza viruses in cynomolgus macaques via intranasal and conjunctival inoculation, which mimics natural infection in humans. H7N9 virus, as well as H7N7 highly pathogenic avian influenza virus, showed more efficient replication and higher pathogenicity in macaques than did H7N1 and H7N3 highly pathogenic avian influenza viruses. These results are different from pathogenicity in chickens as reported previously. Therefore, our results obtained in macaques help to estimate the pathogenicity of H7 avian influenza viruses in humans. (C) 2016 Elsevier Inc. All rights reserved.