Multi-objective blood glucose control for type 1 diabetes
Multi-objective blood glucose control for type 1 diabetes
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DOI：
10.1007/s11517-009-0453-0
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发表时间：
2009-03-01
影响因子：
3.2
通讯作者：
Pistikopoulos, Efstratios N.
中科院分区：
文献类型：
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作者：
Dua, Pinky;Doyle, Francis J., III;Pistikopoulos, Efstratios N.
对于 1 型糖尿病患者，自动控制器旨在通过在进餐和运动障碍的情况下输注适量胰岛素，将血糖浓度维持在 60-120 mg/dL 的理想范围内。超出所需范围的血糖浓度可能对个人健康有害，但浓度低于 60 mg/dL（一种称为低血糖的状态）被认为比浓度高于 120 mg/dL（一种称为高血糖的状态）危害更大。本文提出了两种在基于多参数模型的控制框架内解决此问题的技术。第一种技术将不对称性引入目标函数，以对低血糖偏差的惩罚大于对高血糖偏差的惩罚。第二种技术基于对低血糖约束的满足比对高血糖约束的满足给予更高的优先级。在存在干扰的情况下分析和比较了两种控制技术的性能。
For people with type 1 diabetes, automatic controllers aim to maintain the blood glucose concentration within the desired range of 60-120 mg/dL by infusing the appropriate amount of insulin in the presence of meal and exercise disturbances. Blood glucose concentration outside the desired range can be harmful to an individual's health but concentration below 60 mg/dL, a state known as hypoglycemia, is considered to be more harmful than the concentration above 120 mg/dL, a state known as hyperglycemia. In this paper, two techniques to address this issue within a multi-parametric model based control framework are presented. The first technique introduces asymmetry into the objective function to penalize the deviation towards hypoglycemia more than the deviation towards hyperglycemia. The second technique is based upon placing higher priority on satisfaction of constraints on hypoglycemia than on satisfaction of constraints on hyperglycemia. The performance of both the control techniques is analyzed and compared in the presence of disturbances.