Single-administration vaccines: controlled-release technology to mimic repeated immunizations
Single-administration vaccines: controlled-release technology to mimic repeated immunizations
复制标题
DOI：
10.1016/s0167-7799(98)01272-4
复制
发表时间：
1999-01-01
影响因子：
17.3
通讯作者：
Cleland, JL
中科院分区：
文献类型：
--
作者：
Cleland, JL
从社会中消除疾病的最有效机制是使用疫苗，但通常需要重复接种。然而，单次施用的疫苗制剂自动提供重复施用。一种方法是开发含有疫苗抗原的可注射控释微球制剂，注射后 1-6 个月以脉冲形式释放。脉冲时间取决于聚合物降解速率，而聚合物降解速率由聚合物的组成和分子量决定。这种控释技术可以在单次给药后提供针对疾病的全面保护。
The most effective mechanism for the elimination of disease from society is the use of vaccinations, but these often require repeated administration. However, single-administration vaccine formulations provide the repeated administrations automatically. One approach is the development of injectable controlled-release microsphere formulations containing the vaccine antigen that is released as a pulse 1-6 months after injection. The time of the pulse is dependent upon the rate of polymer degradation, which is dictated by the polymer's composition and molecular weight. This controlled-release technology may provide complete protection against disease after a single administration.