Streptococcus pneumoniae serotypes in Utah adults at the end of the PCV7 era.
Streptococcus pneumoniae serotypes in Utah adults at the end of the PCV7 era.
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PCV7 时代末期犹他州成人中的肺炎链球菌血清型。
DOI：
10.1016/j.vaccine.2011.10.009
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发表时间：
2011
期刊：
影响因子：
5.5
通讯作者：
Byington,CarrieL
中科院分区：
文献类型：
--
作者：
Kendall,BrianA;Dascomb,KristinK;Mehta,RajeshR;Mason,EdwardO;Ampofo,Krow;Pombo,DavidJ;Pavia,AndrewT;Byington,CarrieL
虽然七价肺炎球菌结合疫苗(PCV)在全国范围内减少了疫苗类型侵袭性肺炎球菌病(IPD)，但据报道，犹他州儿童的血清型迅速更换和肺炎旁脓胸增加。儿童疫苗接种对这一人群中成年人的影响尚不清楚。我们在2009年11月至2010年10月期间从山间医疗保健中心实验室确认了117名患有IPD的成年人。我们对61株(52%)储存的分离株进行了血清学分型。我们比较了2009-2010年收集的成人IPD分离株和儿童分离株的血清型分布。PCV7血清型在成人(3%)和儿童(3%)中很少见。新出现的13价PCV血清型3、7F和19A导致大多数成人(63%)和儿童(56%)的IPD。成人分离株中有51株(84%)是23价多糖疫苗中的血清型，66%是PCV13中的血清型。在犹他州，成人和儿童IPD血清型密切相关。犹他州儿童接种PCV13疫苗可能会对犹他州成年人的IPD产生重大影响。
While heptavalent pneumococcal conjugate vaccine (PCV) has decreased vaccine type invasive pneumococcal disease (IPD) nationwide, rapid serotype replacement and increasing parapneumonic empyema, has been reported in Utah children. The effect of pediatric vaccination on adults in this population is unknown. We identified 117 adults with IPD from the Intermountain Healthcare Central Laboratory between November 2009 and October 2010. We serotyped 61 (52%) stored isolates. We compared the serotype distribution of adult IPD isolates with that of pediatric isolates collected in 2009–2010. PCV7 serotypes were rare in adults (3%) and children (3%). Emerging 13-valent PCV serotypes 3, 7F, and 19A caused the majority of IPD in adults (63%) and children (56%). Fifty-one (84%) adult isolates were serotypes included in 23-valent polysaccharide vaccine and 66% in PCV13. Adult and pediatric IPD serotypes are closely associated in Utah. PCV13 vaccination in Utah children is likely to significantly impact IPD in Utah adults.