Temperature distribution analysis for high intensity focused ultrasound breast cancer treatment by numerical simulation
Temperature distribution analysis for high intensity focused ultrasound breast cancer treatment by numerical simulation
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DOI：
10.1109/ultsym.2015.0313
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发表时间：
2015-11
期刊：
影响因子：
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通讯作者：
Mingzhen Zhang;T. Azuma;Xiaolei Qu;Ryuta Narumi;S. Takagi;Y. Matsumoto;K. Okita;H. Furusawa
中科院分区：
文献类型：
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作者：
Mingzhen Zhang;T. Azuma;Xiaolei Qu;Ryuta Narumi;S. Takagi;Y. Matsumoto;K. Okita;H. Furusawa
乳腺癌的发病率在日本急剧上升，在世界上仍然很高。高强度聚焦超声（HIFU）是治疗乳腺癌的一种微创治疗方法。在病灶部位可产生不可逆的组织热凝固。混凝的直接原因是温度升高。本研究试图对高强度聚焦超声治疗乳腺癌的温升分布进行数值分析。乳房模型由真实的患者的MRI图像构建，并且总共研究了4个患者病例。时间研究表明，温度随辐照时间升高，由于乳腺组织异质性，预期目标病灶外可能会出现意外灼伤。空间观察揭示了焦点之外明显的温度上升位置。计算了温升比，定量分析了焦外高温区位置对温升的影响。为了避免意外烧伤，焦点控制变得必要。
Breast cancer incidence is dramatically increasing in Japan and remaining high over the world. High intensity focused ultrasound (HIFU) is a low-invasive treatment method for breast cancer. It could produce irreversible tissue thermal coagulation in focus position. Direct reason for coagulation is temperature-rise. This study tried to numerically analyze temperature-rise distribution for HIFU breast cancer treatment. The breast model is constructed from MRI images of real patient, and a total of 4 patient cases were studied. Temporal study indicates that temperature rises with irradiation time, and possible unexpected burn could be anticipated outside of targeted focus due to heterogeneous breast tissue. Spatial observation reveals noticeable temperature-rise positions outside of focus. Temperature-rise ratio was calculated and quantitative influence of high temperature-rise positions outside of focus was shown. To avoid unexpected burns, focus control turns to be necessary.