Maternal risk factors for severe microtia/atresia in China: A case-control study
Maternal risk factors for severe microtia/atresia in China: A case-control study
复制标题
DOI：
10.1016/j.ijporl.2018.09.033
复制
发表时间：
2018-12-01
影响因子：
1.5
通讯作者：
Chen, Xiaowei
中科院分区：
文献类型：
--
作者：
Liu, Qiang;Fan, Xinmiao;Chen, Xiaowei
目的：小耳畸形是一种严重的外耳畸形。以往的研究报道了小耳畸形的潜在危险因素，而很少有人关注严重的小耳畸形/闭锁。本研究的目的是调查母亲暴露于环境危险因素对中国严重小耳畸形/闭锁患者的影响。病例为2014年1月至2017年10月期间到CIMCH就诊的重度小耳畸形/闭锁患者。共纳入322例重度小耳畸形/闭锁患者和322例按性别、年龄和民族1：1匹配的正常对照。完成设计的问卷并收集数据。结果：重度小耳畸形/闭锁的发病以男性多见（68.6%），单侧多见（80.7%），右侧多见（54.0%）。多因素Logistic回归分析显示先兆流产（OR 4.066，95%CI = 2.360 - 7.007），非甾体类抗炎药（OR 2.576，95%CI = 1.079-6.148），病毒感染（OR 1.933，95%CI = 1.148-3.256），贫血（OR 1.902，95%CI = 1.026-3.526），流产（OR 1.804，95%CI = 1.425-2.285），母亲年龄（OR 1.079，95%CI = 1.015 - 1.148）和父亲年龄（OR 1.061，95%CI = 1.003-1.122）与重度小耳畸形/闭锁的发生有关。结论：本研究结果支持了一些母亲危险因素可能与重度小耳畸形/闭锁有关。
Objective: Microtia/atresia is a severe malformation of the external ear. Previous studies have reported the potential risk factors on microtia, whereas few focused on severe microtia/atresia. The aim of the study was to investigate the effects of maternal exposure to environmental risk factors in patients with severe microtia/atresia in China.Methods: A case-control study was conducted. Cases were patients with severe microtia/atresia who presented to PUMCH between January 2014 and October 2017. A total of 322 patients with severe microtia/atresia were enrolled and 322 normal controls matched 1:1 with the patients by sex, age and nationality were enrolled. The designed questionnaires were completed and data were gathered. Odds ratios were estimated with logistic regression models along with 95% confidence intervals in severe microtia/atresia.Results: Most cases were males(68.6%), and the cases were observed more common in unilateral(80.7%), right-sided (54.0%). Multivariate logistic regression analysis showed that threatened abortion (OR 4.066,95% CI = 2.360-7.007), NSAIDs (OR 2.576,95% CI = 1.079-6.148), virus infection (OR 1.933,95% CI = 1.148-3.256), anemia (OR 1.902,95% CI = 1.026-3.526), miscarriages (OR 1.804,95% CI = 1.425-2.285), maternal age (OR 1.079,95% CI = 1.015-1.148) and paternal age (OR 1.061,95% CI = 1.003-1.122) were associated with a higher risk of severe microtia/atresia.Conclusion: These results support that some maternal risk factors could be associated with severe microtia/atresia.