Transition-Metal-Free, Visible-Light-Enabled Decarboxylative Borylation of Aryl N-Hydroxyphthalimide Esters
Transition-Metal-Free, Visible-Light-Enabled Decarboxylative Borylation of Aryl N-Hydroxyphthalimide Esters
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DOI：
10.1021/jacs.7b03127
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发表时间：
2017-06-07
影响因子：
15
通讯作者：
Glorius, Frank
中科院分区：
文献类型：
--
作者：
Candish, Lisa;Teders, Michael;Glorius, Frank
在这里，我们报告了一种新颖的概念上的反应，通过温和的光诱导氧化还原活化的芳香族羧酸的脱羧反应进行。这项工作构成了廉价和容易制备的N-羟基邻苯二甲酰亚胺酯作为芳基自由基前驱体的第一次应用，并且不需要使用昂贵的过渡金属或配体。该反应操作简单，可扩展，具有广泛的应用范围和官能团的耐受性。
Herein, we report a conceptually novel borylation reaction proceeding via a mild photoinduced decarboxylation of redox-activated aromatic carboxylic acids. This work constitutes the first application of cheap, and easily prepared N-hydroxyphthalimide esters as aryl radical precursors and does not require the use of expensive transition metals or ligands. The reaction operationally simple, scalable, and displays broad scope and functional group tolerance.