Quinolinate differentiates between forebrain and cerebellar NMDA receptors.
Quinolinate differentiates between forebrain and cerebellar NMDA receptors.
复制标题
喹啉酸区分前脑和小脑 NMDA 受体。
DOI：
10.1016/0014-2999(91)90134-c
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发表时间：
1991
影响因子：
5
通讯作者：
Beaton,JA
中科院分区：
文献类型：
--
作者：
Monaghan,DT;Beaton,JA
The potency of N-methyl-D-aspartate (NMDA), ibotenate, L-glutamate and quinolinate for inhibiting [3H]L-glutamate binding to rat brain NMDA receptors was determined by quantitative autoradiography. In contrast to NMDA, ibotenate and L-glutamate, quinolinate more potently displaced binding in forebrain regions than in the cerebellum. Of all drug-region combinations, only quinolinate affinity in the cerebellum was best described by a two-affinity component model (Ki= 24 and 275μM; 45% high affinity). The cerebellum appears to contain a unique quinolinate-insensitive NMDA receptor subtype.
