Lead-induced hypertension: blunted beta-adrenoceptor-mediated functions.
Lead-induced hypertension: blunted beta-adrenoceptor-mediated functions.
复制标题
铅诱发的高血压：β-肾上腺素受体介导的功能减弱。
DOI：
10.1136/bmj.1.6112.551
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发表时间：
1978
影响因子：
--
通讯作者：
J. Ott
中科院分区：
文献类型：
--
作者：
O. Bertel;F R Buhler;J. Ott
并发症。任何药物通过皮肤的吸收取决于多种因素，包括皮肤的状态4——正常皮肤吸收的局部用药量少于活跃性湿疹皮肤。我们还担心某些类固醇制剂的不稳定性可能会导致其变质，从而降低给予患者的“剂量”。这样做的结果可能是灾难性的。英国国家处方规定两周有效期的义务适用于稀释乳膏，但不适用于软膏。尽管如此，这家医院过去两年的做法是，即使是稀释的药膏也会列出有效期。患有长期疾病的患者不喜欢频繁重复开处方而打扰医生，并且希望药物能持续一段时间，这是可以理解的。只要制剂在已知的时间内保持稳定，这通常是一种明智的安排。鉴于此病例，我们认为良性颅内高压并发症的可能性虽然明显不常见，但不应忘记任何接受局部类固醇治疗的患者。
complication. Absorption of any drug through the skin depends on several factors, including the state of the skin4-normal skin absorbing less of the topically applied drug than actively eczematous skin. We are concerned also that the instability of some steroid preparations may cause them to deteriorate, so that the "dose" being given to the patient is lowered. The results of this could be disastrous. The British National Formulary obligation for expiry dates of two weeks applies to diluted creams but not to ointments. Nevertheless, it has been this hospital's practice over the past two years to list expiry dates even on diluted ointments. Patients with long-standing conditions do not like to bother their doctors for frequent repeat prescriptions and understandably like a supply to last some time. This is usually a sensible arrangement as long as the preparations are stable for a known period. As a result of this case we think that the possibility of the complications of benign intracranial hypertension, although obviously uncommon, should not be forgotten in any patient on topical steroid treatment.