Risk of Dementia in Older Breast Cancer Survivors: A Population-Based Cohort Study of the Association with Adjuvant Chemotherapy
Risk of Dementia in Older Breast Cancer Survivors: A Population-Based Cohort Study of the Association with Adjuvant Chemotherapy
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DOI：
10.1111/j.1532-5415.2008.02130.x
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发表时间：
2009-03-01
影响因子：
6.3
通讯作者：
Virning, Beth A.
中科院分区：
文献类型：
--
作者：
Baxter, Nancy N.;Durham, Sara B.;Virning, Beth A.
To assess whether there is an association between delivery of adjuvant chemotherapy to older women with breast cancer and development of dementia over time.Retrospective cohort study using Surveillance, Epidemiology, and End Results (SEER) data linked to Medicare claims data.Women residing in geographic areas included in the SEER registry.Women aged 66 to 80 diagnosed with non-metastatic invasive breast cancer from 1992 to 1999 were included. It was determined whether patients had undergone chemotherapy within 6 months of diagnosis.Whether women developed dementia over time was determined using diagnostic codes. The effect of adjuvant chemotherapy on development of dementia was evaluated, adjusting for confounders using a proportional hazards model stratified for age.Twenty-one thousand three hundred sixty-two women met selection criteria; 2,913 received chemotherapy, and 18,449 did not. Women who received chemotherapy were younger than those who did not (median aged 70 vs 73; P
