Allergic reactions to laboratory animals
Allergic reactions to laboratory animals
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对实验动物的过敏反应
作者：
G. Taylor;G. Davies;R. Altounyan;H. Brown;A. W. Frankland;J. Smith;R. Winch
人们越来越关注处理动物的实验室工作人员的过敏反应，但几乎没有事实证据。英国过敏和临床免疫学学会任命了一个工作组来调查这个问题，在这里我们报告初步的发现，这给了一些问题的规模的想法。我们在两个实验室中使用了问卷，一个是工业实验室，另一个是非工业实验室，但结果非常相似，所以我们在这里合并了它们。474人接受了调查。重点是，在这一人群中，•23%的人在与动物接触的12小时内反复出现一种或多种症状•9%的人有胸部、17%的人有鼻腔、10%的人有眼睛和11%的人有皮肤症状•4%的人不得不停止与动物打交道•接触两年后，过敏的发生率没有随着进一步接触而显著增加•有过敏家族史的人中有22%有症状，没有症状的人中有19%有过敏家族史。这个小得惊人的差异让人对就业前家族史筛查的有效性产生了疑问，这与美国最近一项调查的结果是否存在差异（Lutsky L . 1）。，和Neuman， I., Annals Allergy, 31,201(1975))。
SIR-There is a growing concern about allergic reactions in laboratory workers who handle animals but little factual evidence is available. The Bri· tish Society for Allergy and Clinical Immunology appointed a working party to investigate this subject and here we report preliminary findings, which give some idea of the size of the problem. We used a questionnaire in two laboratories, one industrial and the other non-industrial, but the results were closely similar, so here we amalgamate them. 474 individuals were questioned. Salient points were, that of this population,• 23% had had one or more symptoms occurring repeatedly within 12 hours of animal contact• 9% had had chest, 17% nasal, 10% eye and 11% skin symptoms• 4% had had to stop working with animals• after two years of exposure the incidence of allergy did not increase significantly with further exposure• a family history of allergy was present in 22% of those who reported symptoms, 19% of those who did not. This surprisingly small difference calls into question the usefulness of a preemployment family-history screen, and is M variance with results from a recent survey in the USA (Lutsky L 1., and Neuman, I., Annals Allergy, 31, 201 (1975)).