An efficient green synthesis of proline-based cyclic dipeptides under water-mediated catalyst-free conditions
An efficient green synthesis of proline-based cyclic dipeptides under water-mediated catalyst-free conditions
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DOI：
10.1016/j.tetlet.2009.12.134
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发表时间：
2010-03-03
影响因子：
1.8
通讯作者：
Hong, In Seok
中科院分区：
文献类型：
--
作者：
Thajudeen, Habeebullah;Park, Kyungseok;Hong, In Seok
以N-Boc保护的二肽甲酯为原料，水为溶剂，在无催化剂条件下合成了L-脯氨酸环二肽。一锅锅保护和循环使用是关键步骤，提供了一种高效和环保的方法。清洁的反应条件、易于分离和环二肽的良好产率是所建议的方法的显著特点(C)2010爱思唯尔有限公司版权所有。
L-Proline-based cyclic dipeptides were synthesized from N-Boc-protected dipeptide methyl esters under catalyst-free condition using water as a solvent. One-pot deprotection and cyclization have been used is the key steps, providing an efficient and environmentally friendly approach. Clean reaction conditions, easy isolation, and good yields of cyclic dipeptides are the salient features of the proposed methodology (C) 2010 Elsevier Ltd All rights reserved.